(E)-1-(4-(pyrimidin-2-yloxy)phenyl)-3-((3-(trifluoromethyl)phenyl)amino)prop-2-en-1-one CAS 1164457-65-1
| CAS No. | 1164457-65-1 |
| Molecular Formula | C20H14F3N3O2 |
| Molecular Weight | 385.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (E)-1-(4-(pyrimidin-2-yloxy)phenyl)-3-((3-(trifluoromethyl)phenyl)amino)prop-2-en-1-one.
(E)-1-(4-(pyrimidin-2-yloxy)phenyl)-3-((3-(trifluoromethyl)phenyl)amino)prop-2-en-1-one (CAS 1164457-65-1) is a high-purity analytical reference standard with the molecular formula C20H14F3N3O2 and a molecular weight of 385.34 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, (E)-1-(4-(pyrimidin-2-yloxy)phenyl)-3-((3-(trifluoromethyl)phenyl)amino)prop-2-en-1-one is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 385.34 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H14F3N3O2 |
| Molecular Weight | 385.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related E Standards
- 4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (CAS 877636-42-5)
- Ethyl 4-(2-(2-(pyrimidin-2-ylamino)thiazol-4-yl)acetamido)piperidine-1-carboxylate (CAS 1226429-72-6)
- (E)-3-(3-(pyrimidin-2-yloxy)phenyl)-2-tosylacrylonitrile (CAS 861210-23-3)
- 4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 2,6-difluorobenzoate (CAS 877636-01-6)
- 4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-(tert-butyl)benzoate (CAS 877635-40-0)
- 1-(2-((4-(Pyrimidin-2-yl)piperazin-1-yl)sulfonyl)ethyl)-3-(thiophen-2-yl)urea (CAS 1207005-68-2)
- 4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 2-methoxybenzoate (CAS 877635-43-3)
- 4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 2-phenoxyacetate (CAS 877636-97-0)
Recommended Standards
- N2,N6-Diphenyl-4-(trifluoromethyl)pyridine-2,6-dicarboxamide (CAS 1092344-79-0)
- Farnesyl Pyrophosphate-d3 Triammonium Salt (CAS 1366590-48-8)
- 2,2-Dimethyl-5-({4-[5-(trifluoromethyl)-2-pyridinyl]piperazino}methylene)-1,3-dioxane-4,6-dione (CAS 1022052-14-7)
- N-(1-{[4-(trifluoromethyl)phenyl]methyl}-1H-indazol-3-yl)furan-2-carboxamide (CAS 1569076-11-4)
- 5-(5-Bromo-2-thienyl)-1,3,4-oxadiazol-2-amine (CAS 1016734-35-2)
- N'-((2,6-dichloropyridin-3-yl)methylene)-4-methylbenzenesulfonohydrazide (CAS 1820748-57-9)
- {4-[(morpholine-4-sulfonyl)methyl]phenyl}methanamine (CAS 1040344-10-2)
- 4-Bromo-2-chloro-1-benzenesulfonyl Chloride (CAS 351003-52-6)
- 2-((4-Ethyl-5-(furan-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(m-tolyl)acetamide (CAS 557069-38-2)
- 4-(2,6-Difluoro-4-(trifluoromethyl)phenoxy)-3-fluoroaniline (CAS 2244086-72-2)
- 2-(Furan-3-yl)-1H-imidazole-5-carbaldehyde (CAS 279251-04-6)
- 1-Methyl-2-oxo-2,3-dihydro-1h-indole-5-carbaldehyde (CAS 933728-55-3)
- (2-Amino-1-phenylpropyl)dimethylamine (CAS 104177-54-0)
- Insulin Degludec Impurity 16 (CAS CATO-C4X-215716)
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