(E)-1-[2-(4-Chlorophenyl)-4-methyl-1,3-thiazol-5-yl]-3-(4-methoxyphenyl)-2-propen-1-one CAS 1164520-79-9
| CAS No. | 1164520-79-9 |
| Molecular Formula | C20H16ClNO2S |
| Molecular Weight | 369.86 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (E)-1-[2-(4-Chlorophenyl)-4-methyl-1,3-thiazol-5-yl]-3-(4-methoxyphenyl)-2-propen-1-one is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(E)-1-[2-(4-Chlorophenyl)-4-methyl-1,3-thiazol-5-yl]-3-(4-methoxyphenyl)-2-propen-1-one (CAS 1164520-79-9), molecular formula C20H16ClNO2S and molecular weight 369.86 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (E)-1-[2-(4-Chlorophenyl)-4-methyl-1,3-thiazol-5-yl]-3-(4-methoxyphenyl)-2-propen-1-one (C20H16ClNO2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (E)-1-[2-(4-Chlorophenyl)-4-methyl-1,3-thiazol-5-yl]-3-(4-methoxyphenyl)-2-propen-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H16ClNO2S |
| Molecular Weight | 369.86 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related E Standards
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Recommended Standards
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- 3-Methyl-1-propyl-1h-pyrazol-4-amine (CAS 1006457-04-0)
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- 6-(Difluoromethyl)-3-fluoro-2-methoxypyridin-4-amine (CAS 1806813-68-2)
- 2,6-Diamino-5-iminopyrimidin-4(5H)-one (CAS 72091-25-9)
- 2-Amino-N-butyl-5-chlorobenzamide (CAS 18014-57-8)
- 4628-94-8 Dipotassium 1,3,4-thiadiazole-2,5-dithiolate 1,3,4-Thiadiazolidine-2,5-dithione, potassium salt (1:2) 1,3,4-Thiadiazolidine-2,5-dithione, dipotassium salt 2,5-Dimercapto-1,3,4-thiadiazole, dipotassium salt EINECS 225-043-4 (CAS 4628-94-8)
- Allo-Thr5-Tirzepatide (CAS CATO-CPTD788934)
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