1-(5-Nitrothiophene-2-carbonyl)piperazine hydrochloride CAS 1171194-70-9
| CAS No. | 1171194-70-9 |
| Molecular Formula | C9H11N3O3S |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-(5-Nitrothiophene-2-carbonyl)piperazine hydrochloride (CAS 1171194-70-9), molecular formula C9H11N3O3SHCl and molecular weight 277.72 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-(5-Nitrothiophene-2-carbonyl)piperazine hydrochloride (C9H11N3O3SHCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 1-(5-Nitrothiophene-2-carbonyl)piperazine hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H11N3O3S HCl |
| Molecular Weight | 277.72 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Nitrothiophene Standards
- 2-Nitrothiophene-3-carboxylic acid (CAS 100114-16-7)
- Ethyl 5-nitrothiophene-3-carboxylate (CAS 100958-70-1)
- 5-Methyl-3-nitrothiophene-2-carbonitrile (CAS 1027512-56-6)
- 4-(5-Nitrothiophene-2-carbonyl)piperazin-2-one (CAS 1030815-32-7)
- 6-Benzyl-2-(5-nitrothiophene-2-carboxamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride (CAS 1216591-03-5)
- 2-Nitrothiophene-3-sulfonamide (CAS 1421601-53-7)
- 2-nitrothiophene-3-sulfonyl chloride (CAS 1421602-28-9)
- 3-Nitrothiophene-2,5-dicarboxylic acid (CAS 1437794-39-2)
Recommended Standards
- 6,8-Dibromo-2-oxo-2H-chromene-3-carboxylic acid (CAS 3855-87-6)
- 3-(5-Bromo-2-chlorophenoxy)-2,2-dimethylpropanoic acid (CAS 1541543-41-2)
- (6-Methoxybenzofuran-3-yl)methanol (CAS 650616-60-7)
- 3-(Hexadecyloxy)-2-hydroxybenzaldehyde (CAS 52049-39-5)
- 4-(Benzyloxy)-5-bromo-2,3-difluorobenzoic acid (CAS 2404734-36-5)
- 1-[4-(piperidin-3-ylmethyl)-1,4-diazepan-1-yl]ethan-1-one hydrochloride (CAS 1864061-93-7)
- N4-Acetyl-2-deoxy-5-O-DMT-2-fluorocytidine (CAS 159414-98-9)
- tert-Butyl 3-[(butan-2-yl)amino]-2-methylpropanoate (CAS 1221341-82-7)
- 5'-Fluoro-2'-methyl-[1,1'-biphenyl]-4-carbaldehyde (CAS 1183043-65-3)
- D-Val23-Tirzepatide (CAS CATO-CPTD788911)
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