Isavuconazole Impurity 24 CAS 1176988-44-5
| CAS No. | 1176988-44-5 |
| Molecular Formula | C22H17F2N5OS |
| Molecular Weight | 437.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Isavuconazole Impurity 24 (C22H17F2N5OS) contains a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 437.47 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Isavuconazole Impurity 24 (CAS 1176988-44-5, C22H17F2N5OS) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H17F2N5OS |
| Molecular Weight | 437.47 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Isavuconazole Standards
- Isavuconazole (CAS 241479-67-4)
- Isavuconazole Impurity 26 (CAS CATO-C4X-123626)
- Isavuconazole-d4 (CAS 1346598-58-0)
- Isavuconazole Impurity 198 (CAS CATO-C4X-1236198)
- Isavuconazole Impurity 203 (CAS CATO-C4X-1236203)
- Isavuconazole Impurity 119 (CAS CATO-C4X-1236119)
- Isavuconazole Impurity 41 (CAS CATO-C4X-123641)
- Isavuconazole Impurity 140 (CAS CATO-C4X-1236140)
Recommended Standards
- (2R,3S)-Isavuconazole Impurity 25 (CAS 1797905-83-9)
- N-(4-(2-(1,3-dioxoisoindolin-2-yl)ethyl)thiazol-2-yl)-3,4-dimethoxybenzamide (CAS 866041-09-0)
- N-(2,4-Difluorophenyl)-2-((5-(pyridin-4-yl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 578757-87-6)
- Ravuconazole (CAS 182760-06-1)
- Urapidil Impurity 3 (CAS 34654-81-4)
- Benidipine Impurity 8 (CAS CATO-C4X-11208)
- Promethazine Impurity 62 (CAS CATO-C4X-141862)
- Vericiguat impurity 44 (CAS CATO-C4X-289644)
- n-Cyclohexyl-4,5-dimethylthiophene-2-carboxamide (CAS 832736-51-3)
- 5-Fluoro-2-(2-methyl-1h-imidazol-1-yl)benzaldehyde (CAS 1096786-15-0)
- 4-Iodo-1'-methyl-1'H,2H-3,4'-bipyrazole (CAS 2163263-17-8)
- 4-[(cyclopropylcarbonyl)amino]butanoic acid (CAS 926242-54-8)
- 2-chloro-3-[2-nitro-4-(trifluoromethyl)phenoxy]pyridine (CAS 219928-52-6)
- Des-Lys16-Tirzepatide (CAS CATO-CPTD788957)
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