Roxithromycin EP Impurity F CAS 118267-18-8
| CAS No. | 118267-18-8 |
| Molecular Formula | C40H74N2O15 |
| Molecular Weight | 823.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Roxithromycin EP Impurity F.
Roxithromycin EP Impurity F (CAS 118267-18-8) is a certified pharmaceutical impurity reference standard with the molecular formula C40H74N2O15 and a molecular weight of 823.02 g/mol.
The molecular framework of Roxithromycin EP Impurity F (C40H74N2O15) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Roxithromycin EP Impurity F meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C40H74N2O15 |
| Molecular Weight | 823.02 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 2 |
Related Roxithromycin Standards
- Roxithromycin EP Impurity E (CAS 1460313-66-9)
- Roxithromycin EP Impurity H (CAS 425365-65-7)
- Roxithromycin EP Impurity D (CAS 134931-00-3)
- Roxithromycin (CAS 80214-83-1)
- Roxithromycin EP Impurity J (CAS 134834-12-1)
- Roxithromycin Impurity 24 (CAS CATO-C4X-130324)
- Roxithromycin-d7 (CAS CATO-C4X-130322)
- Roxithromycin-d7 (CAS CATO-CCAD300664)
Recommended Standards
- tert-Butyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(4,4'-(biphenyl-4,4'-diyl)bis(1H-imidazole-4,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate (CAS 1009119-17-8)
- 6''-O-Acetylsaikosaponin A (CAS 64340-46-1)
- N,N'-Bis[4-(diphenylamino)phenyl]-N,N'-diphenylbenzidine (CAS 209980-53-0)
- H-Leu-Trp-Met-Arg-Phe-Ala-OH (CAS 53214-98-5)
- Letrozole Impurity 17 (CAS 112809-27-5)
- Enalapril EP Impurity B (CAS 82717-96-2)
- Mirogabalin Impurity 80 (CAS CATO-C4X-292480)
- Topiroxostat Impurity 21 (CAS CATO-C4X-105521)
- 1-(thiophen-2-yl)piperazin-2-one (CAS 1284355-06-1)
- 5-Chloro-N-methyl-1H-benzo[d]imidazol-2-amine (CAS 929338-84-1)
- 5-Fluorobicyclo[3.1.1]Heptane-1-carboxylic acid (CAS 2231674-28-3)
- (3R,4R,5S,6R)-6-(acetoxymethyl)-3-azidotetrahydro-2H-pyran-2,4,5-triyl triacetate (CAS 171032-74-9)
- Methyl 6-(piperidin-1-yl)nicotinate (CAS 132521-82-5)
- Tirzepatide Impurity 15 (CAS CATO-C4X-324015)
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