3-Chloro-6-(2-fluorophenyl)-4-methylpyridazine CAS 118270-17-0
| CAS No. | 118270-17-0 |
| Molecular Formula | C11H8ClFN2 |
| Molecular Weight | 222.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Chloro-6-(2-fluorophenyl)-4-methylpyridazine (CAS 118270-17-0) is a high-purity analytical reference standard with the molecular formula C11H8ClFN2 and a molecular weight of 222.65 g/mol.
Structurally, 3-Chloro-6-(2-fluorophenyl)-4-methylpyridazine (C11H8ClFN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 222.65 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H8ClFN2 |
| Molecular Weight | 222.65 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 4-Chloro-5-fluoro-6-methyl-2-phenylpyrimidine (CAS 1000931-50-9)
- 4-Chloro-2-[(4-fluorophenyl)methyl]pyrimidine (CAS 1156238-27-5)
- 4-chloro-6-(2-fluorophenyl)-2-methylpyrimidine (CAS 1159816-02-0)
- 3-Chloro-4-methoxybenzenesulfonic acid (CAS 118795-71-4)
- 4-Chloro-2-(2-fluorophenyl)-6-methylpyrimidine (CAS 1188233-71-7)
- 2-Chloro-6-methoxypyridine-3-sulfonamide (CAS 1208081-15-5)
- 4-chloro-6-(3-fluorophenyl)-2-methylpyrimidine (CAS 1256638-62-6)
- 5-(3-Chloro-4-fluorophenyl)pyridin-2-amine (CAS 1314985-70-0)
Recommended Standards
- 2-(4-(Chloromethyl)phenyl)-5-fluoropyrimidine (CAS 1139432-30-6)
- (5-Methoxypyrazin-2-yl)methanesulfonyl chloride (CAS 1196146-01-6)
- 5-(aminocarbonyl)-1-methyl-1H-pyrrole-3-sulfonyl chloride (CAS 1000931-98-5)
- (2-Methoxypyrimidin-5-yl)methanesulfonyl chloride (CAS 1196155-67-5)
- 2-Fluoro-5-methanesulfonylbenzene-1-sulfonyl chloride (CAS 1744-09-8)
- (4-(1,1-Difluoroethyl)pyrimidin-5-yl)methanamine (CAS 1427195-04-7)
- (S)-Methyl 2-(benzylamino)-3-(benzyloxy)propanoate (CAS 746598-47-0)
- Ticlopidine EP Impurity E Bromide (CAS 73099-88-4)
- N-{[2-chloro-6-(1H-pyrrol-1-yl)phenyl]methyl}-3-methylbut-2-enamide (CAS 866042-77-5)
- 5-Fluoro-2-methyl-n-propylbenzenesulfonamide (CAS 1094795-76-2)
- 4-Butyl-N,N-diphenylaniline (CAS 472960-35-3)
- 1,5-Dicyclopropyl-1H-indole-3-carbaldehyde (CAS 1350760-59-6)
- 2-Chloro-5-(2-methoxybenzoyl)pyridine (CAS 1187167-78-7)
- Tirzepatide Impurity 11 TFA salt (CAS CATO-C4X-324011)
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