Tafamidis Impurity 3 CAS 1183404-30-9
| CAS No. | 1183404-30-9 |
| Molecular Formula | C14H9Cl2NO4 |
| Molecular Weight | 326.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tafamidis Impurity 3.
As a process- or degradation-related impurity, Tafamidis Impurity 3 (CAS 1183404-30-9, C14H9Cl2NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C14H9Cl2NO4, Tafamidis Impurity 3 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 326.13 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H9Cl2NO4 |
| Molecular Weight | 326.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Tafamidis Standards
- Tafamidis Impurity 1 (CAS 1184581-58-5)
- Tafamidis Impurity 9 (CAS 1395964-06-3)
- Tafamidis Impurity 13 (CAS CATO-C4X-287713)
- Tafamidis Impurity 7 (CAS CATO-C4X-28777)
- Tafamidis (CAS 594839-88-0)
- Tafamidis impurity 10 (CAS CATO-C4X-287710)
- Tafamidis Impurity 6 (CAS 1507158-86-2)
- Tafamidis Impurity 15 (CAS CATO-C4X-287715)
Recommended Standards
- Ethyl 5-(3-Bromo-4-methoxyphenyl)isoxazole-3-carboxylate (CAS 1188165-02-7)
- Glycerol Impurity 48 (CAS CATO-C4X-217148)
- 2-(6-Bromonaphthalen-2-yl)-2-nitropropane-1,3-diol (CAS 1225346-96-2)
- n-(4-Iodophenyl)-1-methyl-1h-pyrrole-2-carboxamide (CAS 853724-57-9)
- Fesoterodine Impurity N14 (CAS 895137-81-2)
- Ornidazole Impurity 95 (CAS CATO-C4X-133195)
- Dalilesen Impurity 20 (CAS CATO-C4X-301020)
- 2-Cyano-4,6-difluoro-benzoic acid methyl ester (CAS 1807177-92-9)
- N-(5-amino-2-methoxyphenyl)thiophene-2-carboxamide (CAS 926218-27-1)
- Sodium Gualenate Impurity 2 (CAS CATO-C4X-29272)
- 1-Ethyl-2-(furan-3-yl)piperidine (CAS 1355226-05-9)
- 1,3-Dihydroisobenzofuran (CAS 496-14-0)
- 3-(aminomethyl)-5-bromofuran-2-carboxylic acid (CAS 2932454-11-8)
- Allo-D-Ile27-Tirzepatide (CAS CATO-CPTD788961)
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