Nortriptyline EP Impurity E-D3 HCl CAS 1184983-42-3
| CAS No. | 1184983-42-3 |
| Molecular Formula | - |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C20H18D3NHCl, Nortriptyline EP Impurity E-D3 HCl contains deuterium isotope labeling, a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 314.87 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Nortriptyline EP Impurity E-D3 HCl (CAS 1184983-42-3, C20H18D3NHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H18D3N HCl |
| Molecular Weight | 314.87 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Nortriptyline Standards
- Nortriptyline Impurity 23 (CAS 1154-08-1)
- Nortriptyline EP Impurity I (CAS 1210-34-0)
- Nortriptyline Impurity 21 (CAS 1562-52-3)
- Nortriptyline EP Impurity G (CAS 16234-88-1)
- Nortriptyline Impurity 1 HCl (CAS 1750-07-8)
- Nortriptyline EP Impurity H (CAS 24755-73-5)
- Nortriptyline EP Impurity B (CAS 303-50-4)
- Nortriptyline EP Impurity F-d3 HCl (CAS 342611-00-1)
Recommended Standards
- Piperacillin EP Impurity R (CAS CATO-C4X-173225)
- Apremilast Impurity 48 (CAS 1450657-28-9)
- Cephalexin Impurity 44 (CAS CATO-C4X-126144)
- 2,3,6-Trifluoroaniline (CAS 67815-56-9)
- ((1s,3R,5S,7s)-4,4-Difluoroadamantan-1-yl)methanol (CAS 1283719-51-6)
- 4-Amino-3-nitrobenzenesulfonic acid (CAS 616-84-2)
- 1-(4-Chlorophenyl)pentane-1,3-dione (CAS 26732-06-9)
- N-(2,5-Dimethylphenyl)-3-(methylsulfonyl)benzamide (CAS 896296-83-6)
- 2-(2,3-Dichlorophenyl)-2-(methylamino)acetic acid (CAS 1218741-14-0)
- Semaglutide Impurity 139 (CAS CATO-C4X-2226139)
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