Nortriptyline EP Impurity B CAS 303-50-4
| CAS No. | 303-50-4 |
| Molecular Formula | C19H19N |
| Molecular Weight | 261.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Nortriptyline EP Impurity B (C19H19N) contains a nitrogen-containing heterocyclic scaffold, a nitrile group. Its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Nortriptyline EP Impurity B (CAS 303-50-4, C19H19N) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nortriptyline EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H19N |
| Molecular Weight | 261.36 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Nortriptyline Standards
- Nortriptyline Impurity 23 (CAS 1154-08-1)
- Nortriptyline EP Impurity H (CAS 24755-73-5)
- Nortriptyline EP Impurity J (CAS 4317-14-0)
- Nortriptyline Impurity 21 (CAS 1562-52-3)
- Nortriptyline-D3 N-nitroso (CAS CATO-C4X-34112)
- Nortriptyline EP Impurity I (CAS 1210-34-0)
- Nortriptyline EP Impurity G (CAS 16234-88-1)
- Nortriptyline EP Impurity E-D3 HCl (CAS 1184983-42-3)
Recommended Standards
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- 2-(Pyridin-2-yloxy)ethanol (CAS 56446-64-1)
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