Pitavastatin Impurity 54 CAS 1187966-95-5
| CAS No. | 1187966-95-5 |
| Molecular Formula | C20H14FN |
| Molecular Weight | 287.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 287.33 g/mol gives Pitavastatin Impurity 54 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Pitavastatin Impurity 54 (CAS 1187966-95-5), a pharmacopoeial impurity reference standard (molecular formula C20H14FN, MW 287.33 g/mol) used for the identification and quantification of trace impurities in APIs.
Pitavastatin Impurity 54 (C20H14FN) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H14FN |
| Molecular Weight | 287.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Pitavastatin Standards
- Pitavastatin Impurity 55 (CAS 1187966-94-4)
- Pitavastatin Impurity 25 (CAS CATO-C4X-103725)
- Pitavastatin Impurity 91 (CAS CATO-C4X-103791)
- Pitavastatin Formyl Impurity (CAS 121660-37-5)
- Pitavastatin Hydroxymethyl Impurity (CAS 24922-02-9)
- Pitavastatin Impurity 81 (CAS CATO-C4X-103781)
- Pitavastatin Impurity 96 (CAS 121660-11-5)
- Pitavastatin Impurity 97 (CAS 1356998-79-2)
Recommended Standards
- tert-butyl N-[(benzenesulfonyl)methyl]-N-hydroxycarbamate (CAS 870300-76-8)
- Amisulpride Impurity 27 (CAS 1258980-24-3)
- tert-butyl 4-(2-ethoxy-2-oxoethylidene)-3-fluoropiperidine-1-carboxylate (CAS 317360-03-5)
- Amisulpride Impurity 42 (CAS 31925-29-8)
- Netupitant Impurity 23 (CAS CATO-C4X-122323)
- N-Nitroso Gentamicin impurity 29 (CAS CATO-C4X-148029)
- Acemetacin EP Impurity F (CAS 76812-49-2)
- N-methyl-1-(5-methyl-1-phenyl-1H-pyrazol-4-yl)methanamine (CAS 1031843-22-7)
- 2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-((methylthio)methoxy)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one (CAS 90813-68-6)
- 2,9-Dichloro-1,10-phenanthroline (CAS 29176-55-4)
- Bis(4-tert-butylphenyl)iodonium p-toluenesulfonate (CAS 142342-33-4)
- 1,4-Bis(bromomethyl)-2,5-dioctylbenzene (CAS 870704-21-5)
- Methyl 3-(7-(4-chlorophenyl)-8-cyano-[1,2,4]triazolo[1,5-a]pyridin-2-yl)propanoate (CAS 866133-35-9)
- Acetyl Tetrapeptide-11 (CAS 928006-88-6)
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