Acemetacin EP Impurity F CAS 76812-49-2
| CAS No. | 76812-49-2 |
| Molecular Formula | C23H20ClNO8 |
| Molecular Weight | 473.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Acemetacin EP Impurity F (CAS 76812-49-2, C23H20ClNO8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Acemetacin EP Impurity F (C23H20ClNO8) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 473.86 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H20ClNO8 |
| Molecular Weight | 473.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Acemetacin Standards
- Acemetacin EP Impurity D (CAS 76812-64-1)
- Acemetacin EP Impurity E (CAS 75302-98-6)
- Acemetacin EP Impurity C (CAS CATO-C4X-33821)
- Acemetacin-D4 (CAS 1196151-16-2)
- Acemetacin (CAS 53164-05-9)
- Acemetacin acyl-β-D-glucuronide (CAS 1260603-31-3)
- Acemetacin Impurity 1 (CAS 77914-62-6)
- Acemetacin EP Impurity B Potassium Salt (CAS 28751-45-3)
Recommended Standards
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- 2-(1-Methyl-1h-pyrrol-2-yl)-2-morpholinoacetonitrile (CAS 80886-11-9)
- 1-(4-((6-Chloropyrazin-2-yl)methyl)azepan-1-yl)ethan-1-one (CAS 1316221-05-2)
- 6-Amino-5-(morpholin-4-yl)-1-propyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 500696-68-4)
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- 3,3,3-Trifluoro-2-methoxypropan-1-amine (CAS 1157122-11-6)
- Semaglutide impurity 94 (CAS CATO-C4X-222694)
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