Citalopram EP Impurity D HBr CAS 1188264-72-3
| CAS No. | 1188264-72-3 |
| Molecular Formula | C19H19FN2O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Citalopram EP Impurity D HBr is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Citalopram EP Impurity D HBr (CAS 1188264-72-3, C19H19FN2OHBr) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Citalopram EP Impurity D HBr (C19H19FN2OHBr) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 391.28 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Citalopram EP Impurity D HBr meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H19FN2O HBr |
| Molecular Weight | 391.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Citalopram Standards
- Citalopram Impurity 38 (CAS 103146-26-5)
- Citalopram Impurity 17 (CAS 1187671-15-3)
- Citalopram-d6 N-Oxide (CAS 1189652-54-7)
- Citalopram-d6 (CAS 1190003-26-9)
- (R)-Citalopram-d6 N-Oxide (CAS 1217669-62-9)
- (S)-Citalopram-d6 N-Oxide (CAS 1217710-65-0)
- (S)-Citalopram-d6 Oxalate (CAS 1217733-09-9)
- (R)-Citalopram N-Oxide (CAS 1217761-31-3)
Recommended Standards
- Roxadustat Impurity 72 (CAS CATO-C4X-221372)
- Sofosbuvir Impurity 14 (CAS CATO-C4X-105214)
- Mesalazine N-Propionyl Impurity (CAS 93968-80-0)
- 1,12-Dodecanedioic-d20 Acid (CAS 89613-32-1)
- methyl 4-(1-methyl-1h-pyraZol-4-yl)-2,4-dioxobutanoate (CAS 875554-21-5)
- 1,2,3',4'-Tetrahydro-1'H-spiro[indole-3,2'-quinazoline]-2-one (CAS 543745-35-3)
- 1-Acetyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-6(5H)-one (CAS 80862-09-5)
- 7-(Diethylamino)-3-(5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)-2H-chromen-2-one (CAS 252551-75-0)
- n-Cyclooctyltetrahydro-2h-pyran-4-amine (CAS 885281-07-2)
- Endo-38a-Pro-Exenatide trifluoroacetate salt (CAS 1678416-95-9)
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