(R)-Citalopram N-Oxide CAS 1217761-31-3
| CAS No. | 1217761-31-3 |
| Molecular Formula | C20H21FN2O2 |
| Molecular Weight | 340.39 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
(R)-Citalopram N-Oxide (CAS 1217761-31-3) is a high-purity analytical reference standard with the molecular formula C20H21FN2O2 and a molecular weight of 340.39 g/mol.
(R)-Citalopram N-Oxide (C20H21FN2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H21FN2O2 |
| Molecular Weight | 340.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related R Standards
- Citalopram Nitrile Oxide (CAS 1346601-93-1)
- Citalopram EP Impurity B (Escitalopram EP Impurity B ) (CAS 411221-53-9)
- Citalopram EP Impurity C (CAS 372941-54-3)
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- Citalopram Impurity 11 (CAS CATO-C4X-110911)
- Citalopram Impurity 14 (CAS CATO-C4X-110914)
- Citalopram Impurity 15 (CAS 488787-59-3)
- Citalopram Impurity 68 (CAS 481047-48-7)
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