Efavirenz Impurity 5 CAS 1189491-03-9
| CAS No. | 1189491-03-9 |
| Molecular Formula | C21H17ClF3NO3 |
| Molecular Weight | 423.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Efavirenz Impurity 5 (CAS 1189491-03-9, C21H17ClF3NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C21H17ClF3NO3, Efavirenz Impurity 5 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 423.81 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Efavirenz Impurity 5 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H17ClF3NO3 |
| Molecular Weight | 423.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Efavirenz Standards
- Efavirenz Impurity 1 (CAS 353270-77-6)
- Efavirenz Impurity 11 (CAS CATO-C4X-162711)
- Efavirenz Impurity 4 (CAS 174819-21-7)
- Efavirenz Impurity 12 (CAS 221177-56-6)
- Efavirenz Impurity 19 (CAS 173676-60-3)
- Efavirenz Impurity 9 (CAS 209414-26-6)
- Efavirenz Impurity 7 (CAS 211563-41-6)
- (S)-Efavirenz N-β-D-GlucuronideDiscontinued (CAS 252343-21-8)
Recommended Standards
- (2Z)-3-{6-chloro-2-phenylimidazo[1,2-a]pyridin-3-yl}-2-[3-(trifluoromethyl)phenyl]prop-2-enenitrile (CAS 478248-60-1)
- Benzalkonium Chloride impurity 5 (CAS 41961-81-3)
- 3-Benzyl-1-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-4-hydroxy-1,2-dihydropyridin-2-one (CAS 478247-74-4)
- 5-Amino-N-(4-(chlorodifluoromethoxy)phenyl)-1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxamide (CAS 524036-00-8)
- Topiroxostat Impurity 5 (CAS 6975-73-1)
- Promethazine Impurity 67 (CAS 7647-63-4)
- Abrocitinib Impurity 1 (CAS CATO-C4X-28841)
- 3-Chloro-5-fluorobenzene-1,2-diamine (CAS 153505-33-0)
- 6-Chloro-3-isopropyl-2-methylquinolin-4-ol (CAS 1342694-46-5)
- tert-Butyl (5-bromo-1H-indol-3-yl)carbamate (CAS 2638559-58-5)
- 2-(4-Bromophenyl)ethyl cyclopropyl ketone (CAS 898762-06-6)
- 2-(Quinoxalin-2-yl)acetaldehyde (CAS 545423-99-2)
- (2,3-Dimethylquinoxalin-6-yl)methanamine (CAS 65833-71-8)
- Cyclolinopeptide B (CAS 193139-41-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com