Butylphthalide Impurity 1 CAS 119-67-5
| CAS No. | 119-67-5 |
| Molecular Formula | C8H6O3 |
| Molecular Weight | 150.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Butylphthalide Impurity 1 (CAS 119-67-5, C8H6O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Butylphthalide Impurity 1 (C8H6O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Butylphthalide Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6O3 |
| Molecular Weight | 150.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Butylphthalide Standards
- Butylphthalide Impurity 15 (CAS 3453-64-3)
- Butylphthalide Impurity 5 (CAS 612-20-4)
- Butylphthalide Impurity 25 (CAS 3453-63-2)
- Butylphthalide Impurity 14 (CAS 61658-90-0)
- Butylphthalide Impurity 30 (CAS 17475-41-1)
- Butylphthalide Impurity 16 (CAS 577-56-0)
- Butylphthalide Impurity C165 (CAS 4767-54-8)
- Butylphthalide Impurity 19 (CAS 17369-59-4)
Recommended Standards
- Phenylephrine Impurity 37 (CAS 70935-14-7)
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- Baricitinib Impurity 57 (CAS 2920037-85-8)
- Diazoxide impurity 8 (CAS CATO-C4X-19528)
- Salmeterol Impurity 28 (CAS CATO-C4X-105028)
- (1-(Thiazol-2-yl)azetidin-3-yl)methanol (CAS 1420881-99-7)
- 3-amino-6-(trifluoromethyl)-1,2-dihydropyridin-2-one hydrochloride (CAS 1803587-02-1)
- Roxadustat Impurity 35 (CAS 2370958-34-0)
- (2S,4S)-1-(tert-butoxycarbonyl)-4-(thiophen-2-ylmethyl)pyrrolidine-2-carboxylic acid (CAS 959575-44-1)
- 3-(Bromomethyl)-5-(difluoromethyl)-4-methylpyridin-2-amine (CAS 1806893-86-6)
- rel-(1R,5R)-5-Methyl-3-(3-nitro-4-pyridinyl)-2-cyclohexen-1-ol (CAS 1187055-96-4)
- Acetyl Hexapeptide-38 (CAS 1400634-44-7)
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