Roxadustat Impurity 35 CAS 2370958-34-0
| CAS No. | 2370958-34-0 |
| Molecular Formula | C21H20N2O5 |
| Molecular Weight | 380.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Roxadustat Impurity 35 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 380.39 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Roxadustat Impurity 35 (CAS 2370958-34-0, C21H20N2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Roxadustat Impurity 35 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H20N2O5 |
| Molecular Weight | 380.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 2 |
Related Roxadustat Standards
- Roxadustat Impurity 122 (CAS CATO-C4X-2213122)
- Roxadustat Impurity 148 (CAS CATO-C4X-2213148)
- Roxadustat Impurity 174 (CAS CATO-C4X-2213174)
- Roxadustat Impurity 168 (CAS CATO-C4X-2213168)
- Roxadustat impurity 109 (CAS CATO-C4X-2213109)
- Roxadustat Impurity 95 (CAS CATO-C4X-221395)
- Roxadustat Impurity 139 (CAS CATO-C4X-2213139)
- Roxadustat Impurity 14 (CAS 808119-86-0)
Recommended Standards
- Landiolol Impurity 112 (CAS CATO-C4X-2621112)
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- Relebactam Impurity 114 (CAS 1174019-32-9)
- 1-(4-(4-(3-(Furan-2-yl)-1H-pyrazol-5-yl)piperidin-1-yl)-3-nitrophenyl)ethan-1-one (CAS 1025725-16-9)
- Fluconazole Impurity 76 Dimesylate (CAS CATO-C4X-101976)
- Ammoxetine Impurity C38 (CAS 65653-31-8)
- Relugolix Impurity 153 (CAS 3046102-25-1)
- (1,4-Dimethyl-piperazin-2-yl)-acetic aciddihydrochloride (CAS 462068-51-5)
- 4-Propionylpyridine (CAS 1701-69-5)
- Ethyl 5-[3-fluoro-2-(1h-imidazol-1-yl)phenyl]-1,2,4-oxadiazole-3-carboxylate (CAS 1333915-48-2)
- Dibenzylfluorescein (CAS 97744-44-0)
- LMP-420 (CAS 473870-63-2)
- (2-(3-Fluorophenyl)pyrimidin-5-yl)boronic acid (CAS 2225176-72-5)
- D-Pro37-Tirzepatide (CAS CATO-CPTD788902)
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