Eribulin Impurity 8 CAS 1190091-21-4
| CAS No. | 1190091-21-4 |
| Molecular Formula | C40H59NO11 |
| Molecular Weight | 729.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Eribulin Impurity 8 (CAS 1190091-21-4) is a certified pharmaceutical impurity reference standard with the molecular formula C40H59NO11 and a molecular weight of 729.90 g/mol.
The molecular framework of Eribulin Impurity 8 (C40H59NO11) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Eribulin Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C40H59NO11 |
| Molecular Weight | 729.90 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 1 |
Related Eribulin Standards
- Eribulin (CAS 253128-41-5)
- Eribulin Impurity 6 (CAS CATO-C4X-26506)
- Eribulin Impurity 7 (CAS 1534341-95-1)
- Eribulin Impurity 5 (CAS 253128-15-3)
- Eribulin Impurity 1 (CAS CATO-C4X-26501)
- Eribulin Impurity 2 (CAS 1534341-96-2)
- Eribulin Impurity 3 (CAS CATO-C4X-26503)
- Eribulin mesylate intermediate (CAS 157322-83-3)
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