Dorzagliatin Impurity 1 CAS 1191997-59-7
| CAS No. | 1191997-59-7 |
| Molecular Formula | C12H13ClO3 |
| Molecular Weight | 240.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Dorzagliatin Impurity 1 (CAS 1191997-59-7, C12H13ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Dorzagliatin Impurity 1 (C12H13ClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Dorzagliatin Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H13ClO3 |
| Molecular Weight | 240.68 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
Related Dorzagliatin Standards
- Dorzagliatin Impurity 19 (CAS 2310239-62-2)
- Dorzagliatin Impurity 10 (CAS CATO-C4X-344110)
- Dorzagliatin Impurity 2 (CAS 1191453-79-8)
- Dorzagliatin Impurity 16 (CAS CATO-C4X-344116)
- Dorzagliatin Impurity 12 (CAS CATO-C4X-344112)
- Dorzagliatin Impurity 3 (CAS 1191997-60-0)
- Dorzagliatin Impurity 8 (CAS CATO-C4X-34418)
- Dorzagliatin Impurity 20 (CAS CATO-C4X-344120)
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