Methyl 3-chlorosulfonylthiophene-2-carboxylate CAS 59337-92-7
| CAS No. | 59337-92-7 |
| Molecular Formula | C6H5ClO4S2 |
| Molecular Weight | 240.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl 3-chlorosulfonylthiophene-2-carboxylate.
Methyl 3-chlorosulfonylthiophene-2-carboxylate (CAS 59337-92-7), molecular formula C6H5ClO4S2 and molecular weight 240.68 g/mol, is a CATO reference standard with documented purity and traceability.
Methyl 3-chlorosulfonylthiophene-2-carboxylate (C6H5ClO4S2) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H5ClO4S2 |
| Molecular Weight | 240.68 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 2 |
Recommended Standards
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- 2-Chloro-3,5-dimethylphenol (CAS 5538-41-0)
- Tau Peptide (268-282) trifluoroacetate salt (CAS 330456-37-6)
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