3-Chloro-4-(difluoromethoxy)benzoic acid CAS 1192829-74-5
| CAS No. | 1192829-74-5 |
| Molecular Formula | C8H5ClF2O3 |
| Molecular Weight | 222.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures 3-Chloro-4-(difluoromethoxy)benzoic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
3-Chloro-4-(difluoromethoxy)benzoic acid (CAS 1192829-74-5) is a high-purity analytical reference standard with the molecular formula C8H5ClF2O3 and a molecular weight of 222.57 g/mol.
Based on its molecular formula C8H5ClF2O3, 3-Chloro-4-(difluoromethoxy)benzoic acid contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 222.57 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF2O3 |
| Molecular Weight | 222.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 4-Chloro-2,3-difluoro-5-methoxybenzoic acid (CAS 1879026-31-9)
- 2-Chloro-4-(difluoromethoxy)benzoic acid (CAS 97914-61-9)
- 3-Chloro-5-(difluoromethoxy)benzoic acid (CAS 433926-80-8)
- 4-Chloro-2-(difluoromethoxy)benzoic acid (CAS 97914-60-8)
- 5-Chloro-2-(difluoromethoxy)benzoic acid (CAS 773869-44-6)
- 7-Chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrimidine (CAS 1094260-88-4)
- 7-Chloro-5-(trifluoromethyl)-1H-pyrazolo[4,3-d]pyrimidine (CAS 1211533-12-8)
- 6-Chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidine (CAS 1211590-25-8)
Recommended Standards
- Merrifield resin (200-400 mesh, 1.10-1.45 mmol/g) (CAS 55844-94-5)
- 4-(chlorodifluoromethoxy)benzoic acid (CAS 147992-34-5)
- Fluzoparib Impurity 4 (CAS CATO-C4X-32524)
- Fluzoparib Impurity 3 (CAS CATO-C4X-32523)
- Potassium trifluoro(2-hydroxy-6-(trifluoromethyl)phenyl)borate (CAS 2641216-97-7)
- Mogroside IIIA1 (CAS 88901-42-2)
- CDK2 inhibitor II (CAS 222035-13-4)
- 5-Chloro-4-(piperazin-1-yl)pyridine-3-sulfonamide (CAS 1352531-15-7)
- (1E)-N-(4-Fluoro-3-methylphenyl)-1-(2-fluorophenyl)methanimine (CAS 329699-40-3)
- Fmoc-N-(2,4,6-trimethoxybenzyl)-glycine (CAS 166881-43-2)
- 4-(Difluoromethyl)-5-methoxy-3-(trifluoromethyl)picolinic acid (CAS 1805464-11-2)
- 5-(Bromomethyl)-3-methylisoxazole (CAS 36958-61-9)
- 7-Methoxy-3,4-dihydrobenzo[f][1,4]thiazepin-5(2H)-one (CAS 145903-32-8)
- Galanin Message Associated Peptide (44-59) amide (CAS 125455-59-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com