Fluzoparib Impurity 4 CAS CATO-C4X-32524
| CAS No. | CATO-C4X-32524 |
| Molecular Formula | C6H2ClF3N4 |
| Molecular Weight | 222.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Fluzoparib Impurity 4 (C6H2ClF3N4) is characterized by a nitrile group, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Fluzoparib Impurity 4 (CAS CATO-C4X-32524, C6H2ClF3N4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H2ClF3N4 |
| Molecular Weight | 222.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Fluzoparib Standards
Recommended Standards
- Merrifield resin (200-400 mesh, 1.10-1.45 mmol/g) (CAS 55844-94-5)
- 3-Chloro-4-(difluoromethoxy)benzoic acid (CAS 1192829-74-5)
- 8-Chloro-6-(trifluoromethyl)tetrazolo[1,5-a]pyridine (CAS 242815-92-5)
- 4-(chlorodifluoromethoxy)benzoic acid (CAS 147992-34-5)
- Theophylline Impurity 16 (CAS CATO-C4X-182316)
- Tepotinib impurity 19 (CAS 1103508-21-9)
- Famotidine Impurity 50 (CAS 95853-51-3)
- n-Ethyl-3-(n-methylsulfamoyl)benzamide (CAS 565182-88-9)
- 3-(2-Ethylphenyl)isoxazole-5-carboxylic acid (CAS 1248012-50-1)
- Ethyl 7-fluoro-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate (CAS 1427429-66-0)
- 1-(4-Aminophenoxy)-3-(1H-imidazol-1-yl)propan-2-ol (CAS 878668-47-4)
- Ethyl 4-aminotetrahydrofuran-3-carboxylate hydrochloride (CAS 1956376-72-9)
- 3-Chloro-5-nitropyridine (CAS 22353-33-9)
- Neuropeptide Y (3-36) (human, rat) trifluoroacetate salt (CAS 150138-78-6)
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