Midazolam EP Impurity H CAS 119401-13-7
| CAS No. | 119401-13-7 |
| Molecular Formula | C15H10ClFN2 |
| Molecular Weight | 272.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Midazolam EP Impurity H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Midazolam EP Impurity H (CAS 119401-13-7), a pharmacopoeial impurity reference standard (molecular formula C15H10ClFN2, MW 272.70 g/mol) used for the identification and quantification of trace impurities in APIs.
Midazolam EP Impurity H (C15H10ClFN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C15H10ClFN2 |
| Molecular Weight | 272.70 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Midazolam Standards
- Midazolam Impurity 24 (CAS CATO-C4X-150924)
- Midazolam EP Impurity F (CAS 2886-65-9)
- Midazolam N-Methyl Impurity (CAS 59467-61-7)
- Midazolam Impurity 16 (CAS 59467-64-0)
- Midazolam EP Impurity G (CAS 59467-86-6)
- Midazolam Impurity 43 (CAS CATO-C4X-150943)
- Midazolam Impurity 23 (CAS CATO-C4X-150923)
- 【禁售不询】Midazolam (CAS 59467-70-8)
Recommended Standards
- N1-Butyl-N2-(3-chloro-4-fluorophenyl)oxalamide (CAS 903062-14-6)
- 5-(Chloromethyl)-1-(4-methanesulfonylphenyl)-1h-1,2,3,4-tetrazole (CAS 1094333-67-1)
- N-(3-Chloro-4-fluorophenyl)-2-(morpholin-4-yl)acetamide (CAS 329078-62-8)
- 2-Methoxy-5-(1H-pyrazol-1-yl)benzenesulfonyl chloride (CAS 1189749-71-0)
- Sodium Cromoglicate Impurity 6 (CAS 802857-44-9)
- Vinorelbine Impurity 22 (CAS CATO-C4X-264222)
- Prusogliptin Impurity 16 (CAS CATO-C4X-328416)
- Methyl 2-methyl-4-oxo-4,5,6,7-tetrahydrobenzofuran-3-carboxylate (CAS 91143-41-8)
- 3-(3-(3-Isopropylphenyl)-2-oxoimidazolidin-1-yl)benzoic acid (CAS 651748-77-5)
- 2-Ethyl-4-(2-oxopiperidin-1-yl)benzaldehyde (CAS 1260764-38-2)
- a,a’-Paraxylyl Bismethanethiosulfonate (CAS 3948-46-7)
- 1-Methyl-6-phenyldihydropyrimidine-2,4(1H,3H)-dione (CAS 86762-40-5)
- Mirabegron Impurity 58 (CAS 17790-81-7)
- Insulin degludec (CAS 844439-96-9)
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