Midazolam EP Impurity G CAS 59467-86-6
| CAS No. | 59467-86-6 |
| Molecular Formula | C18H14ClN3 |
| Molecular Weight | 307.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 307.78 g/mol gives Midazolam EP Impurity G distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Midazolam EP Impurity G (CAS 59467-86-6, C18H14ClN3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Midazolam EP Impurity G (C18H14ClN3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 307.78 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Midazolam EP Impurity G under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H14ClN3 |
| Molecular Weight | 307.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Midazolam Standards
- Midazolam Impurity 16 (CAS 59467-64-0)
- Midazolam N-Methyl Impurity (CAS 59467-61-7)
- Midazolam Impurity 43 (CAS CATO-C4X-150943)
- Midazolam Impurity 23 (CAS CATO-C4X-150923)
- 【禁售不询】Midazolam (CAS 59467-70-8)
- Midazolam EP Impurity B (CAS 59469-74-8)
- Midazolam Impurity 28 (CAS CATO-C4X-150928)
- Midazolam EP Impurity F (CAS 2886-65-9)
Recommended Standards
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- N-(3,4-dichlorobenzyl)-2-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-2-yl)acetamide (CAS 860611-62-7)
- (1R,2R)-2-(2-(3-chlorophenyl)-2-oxoethyl)cyclohexane-1-carboxylic acid (CAS 736136-40-6)
- 2-Mercapto-N-(4-methylphenyl)acetamide (CAS 34282-30-9)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com