Camptothecin Impurity N3 CAS 119403-33-7
| CAS No. | 119403-33-7 |
| Molecular Formula | C20H14N2O4 |
| Molecular Weight | 346.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Camptothecin Impurity N3 (CAS 119403-33-7, C20H14N2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C20H14N2O4, Camptothecin Impurity N3 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 346.34 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Camptothecin Impurity N3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H14N2O4 |
| Molecular Weight | 346.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 2 |
Related Camptothecin Standards
- (R)-(-)-Camptothecin (CAS 110351-92-3)
- (R)-Camptothecin (CAS 1083-11-0)
- (S)-(+)-Camptothecin (CAS 7689-03-4)
- Camptothecin Impurity 16 (CAS 870527-52-9)
- (R)-(-)-Camptothecin-d5 (CAS 1329793-44-3)
- (S)-(+)-Camptothecin D5 (CAS 1329616-37-6)
- 7-Methyl Camptothecin (CAS 78287-26-0)
- Camptothecin Impurity 10 (CAS 68426-53-9)
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