Saxagliptin Impurity N52 CAS 1194836-75-3
| CAS No. | 1194836-75-3 |
| Molecular Formula | C25H32F3N3O5 |
| Molecular Weight | 511.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Saxagliptin Impurity N52 (CAS 1194836-75-3) is a certified pharmaceutical impurity reference standard with the molecular formula C25H32F3N3O5 and a molecular weight of 511.53 g/mol.
Based on its molecular formula C25H32F3N3O5, Saxagliptin Impurity N52 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 511.53 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H32F3N3O5 |
| Molecular Weight | 511.53 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Saxagliptin Standards
- Saxagliptin Impurity 89 (CAS CATO-C4X-104989)
- Saxagliptin Impurity 80 (CAS CATO-C4X-104980)
- Saxagliptin Impurity 91 (CAS CATO-C4X-104991)
- Saxagliptin Impurity 87 (CAS CATO-C4X-104987)
- Saxagliptin Impurity 77 (CAS CATO-C4X-104977)
- Saxagliptin Impurity 79 (CAS CATO-C4X-104979)
- Saxagliptin N-Carboxybenzyl (CAS 1408335-73-8)
- Saxagliptin Impurity 66 (CAS CATO-C4X-104966)
Recommended Standards
- Z-Lys(Z)-OSu (CAS 21160-83-8)
- N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[(1S,2S)-2-(dimethylamino)-1,2-diphenylethyl]thiourea (CAS 1233369-41-9)
- Trametinib impurity 14 (CAS CATO-C4X-278214)
- 1-(3,5-Bis(trifluoromethyl)phenyl)-3-(cis-2-(dimethylamino)-1,2-diphenylethyl)thiourea (CAS 1308857-18-2)
- Amisulpride Impurity 31 (CAS 2657666-20-9)
- (E)-Ceftizoxime Impurity 1 (CAS 68403-31-6)
- Carbidopa Impurity 12 (CAS 53832-94-3)
- Ceftiofur Impurity N11 (CAS 80370-59-8)
- [(4-Bromo-3-fluorophenyl)methyl](3-methoxypropyl)amine (CAS 1520544-19-7)
- 6-Amino-4-azaspiro[2.4]Heptan-5-one hydrochloride (CAS 2417777-63-8)
- 2-(((6-Bromopyridin-3-yl)methyl)amino)ethanol (CAS 1353977-74-8)
- 4-Amino-5-[4-(diethylamino)phenyl]-4H-1,2,4-triazole-3-thiol (CAS 851207-76-6)
- 5-[4-(trifluoromethyl)phenyl]-4h-1,2,4-triazol-3-amine (CAS 178556-79-1)
- DAPK Substrate Peptide (CAS 386769-53-5)
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