Trametinib impurity 14 CAS CATO-C4X-278214
| CAS No. | CATO-C4X-278214 |
| Molecular Formula | C25H22FN3O6S |
| Molecular Weight | 511.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Trametinib impurity 14 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Trametinib impurity 14 (CAS CATO-C4X-278214) is a certified pharmaceutical impurity reference standard with the molecular formula C25H22FN3O6S and a molecular weight of 511.52 g/mol.
The molecular framework of Trametinib impurity 14 (C25H22FN3O6S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C25H22FN3O6S |
| Molecular Weight | 511.52 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Trametinib Standards
- Trametinib Impurity 16 (CAS CATO-C4X-278216)
- Trametinib impurity 03 (CAS 871700-24-2)
- Trametinib impurity 12 (CAS 3018911-27-5)
- Trametinib impurity 01 (CAS 871701-87-0)
- Trametinib impurity 5 (CAS CATO-C4X-27825)
- Trametinib Impurity N5 (CAS 1620017-29-9)
- Trametinib impurity 4 (CAS CATO-C4X-27824)
- Trametinib Impurity 12 (CAS 1279693-89-8)
Recommended Standards
- Semaglutide impurity 87 (CAS CATO-C4X-222687)
- Z-Lys(Z)-OSu (CAS 21160-83-8)
- N-Nitroso Gentamicin impurity 29 (CAS CATO-C4X-148029)
- Saxagliptin Impurity N52 (CAS 1194836-75-3)
- Melphalan Impurity 24 (CAS CATO-C4X-198824)
- Pirarubicin Impurity 8 (CAS CATO-C4X-24688)
- Posaconazole Impurity 89 (CAS CATO-C4X-1208189)
- N-Benzyl-N-methyl-2-[N’-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]ethanolamine]ethylamine (CAS 1797817-89-0)
- 3-(3-Aminopropyl)imidazolidine-2,4-dione (CAS 138088-05-8)
- 2,6-Dichloro-4-methylbenzenesulfonamide (CAS 871876-37-8)
- Epinephrine Impurity 27 (CAS 37491-94-4)
- Triethylamine Hydrobromide (CAS 636-70-4)
- Ascorbic Acid EP Impurity F (CAS 89-65-6)
- KALA Amphipathic Peptide (CAS 187987-64-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com