4-Chloro-6-(trifluoromethyl)pyridin-3-amine CAS 1196153-86-2

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-6-(trifluoromethyl)pyridin-3-amine.

4-Chloro-6-(trifluoromethyl)pyridin-3-amine (CAS 1196153-86-2) is a high-purity analytical reference standard with the molecular formula C6H4ClF3N2 and a molecular weight of 196.56 g/mol.

The molecular framework of 4-Chloro-6-(trifluoromethyl)pyridin-3-amine (C6H4ClF3N2) is characterized by a nitrile group, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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