Itraconazole Impurity 73 CAS 1199350-02-1
| CAS No. | 1199350-02-1 |
| Molecular Formula | 2*C35H36Cl2N8O6 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Itraconazole Impurity 73 (CAS 1199350-02-1) is a certified pharmaceutical impurity reference standard with the molecular formula C35H36Cl2N8O6 and a molecular weight of 735.62 g/mol.
The molecular framework of Itraconazole Impurity 73 (C35H36Cl2N8O6) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Itraconazole Impurity 73 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | 2*C35H36Cl2N8O6 |
| Molecular Weight | 735.62 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 21.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 8 |
Related Itraconazole Standards
- Itraconazole Impurity 44 (CAS 103661-14-9)
- Itraconazole Impurity 41 (CAS 106461-41-0)
- Itraconazole Impurity 93 (CAS 110762-98-6)
- Itraconazole 2-Oxo Metabolite (CAS 112560-33-5)
- Itraconazole Impurity 38 (CAS 115897-54-6)
- Itraconazole N-Formyl-Ethlene Impurity (CAS 1199350-00-9)
- Itraconazole-d5(major) (CAS 1217510-38-7)
- Itraconazole-d3 (CAS 1217512-35-0)
Recommended Standards
- Cefoperazone Impurity N11 (CAS 68779-10-2)
- Picosulfate impurity 26 (CAS CATO-C4X-123726)
- Valsartan Impurity 145 (CAS 2624122-60-5)
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- [3-chloro-4-(3-methylpiperidin-1-yl)phenyl]methanamine (CAS 1341165-91-0)
- Liraglutide Impurity 21 TFA Salt (CAS CATO-C4X-199221)
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