Itraconazole Impurity 93 CAS 110762-98-6
| CAS No. | 110762-98-6 |
| Molecular Formula | C13H13Cl2N3O3 |
| Molecular Weight | 330.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Itraconazole Impurity 93 (C13H13Cl2N3O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Itraconazole Impurity 93 (CAS 110762-98-6) is a certified pharmaceutical impurity reference standard with the molecular formula C13H13Cl2N3O3 and a molecular weight of 330.17 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Itraconazole Impurity 93 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H13Cl2N3O3 |
| Molecular Weight | 330.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Itraconazole Standards
- Itraconazole Impurity 57 (CAS CATO-C4X-149757)
- Itraconazole Impurity 95 (CAS CATO-C4X-149795)
- Itraconazole Impurity 23 (CAS 79538-90-2)
- Itraconazole Impurity 5 (CAS 74852-89-4)
- Itraconazole Impurity 18 (CAS 74853-07-9)
- Itraconazole Impurity 13 (CAS 308361-47-9)
- Itraconazole Impurity 25 (CAS 89848-19-1)
- Itraconazole Impurity 54 (CAS 170911-92-9)
Recommended Standards
- Iprodione isomer 1 (CAS 63637-89-8)
- YE-120 (CAS 383124-82-1)
- Iprodione (CAS 36734-19-7)
- N-(4-Bromophenyl)-4-fluorobenzenesulfonamide (CAS 727-32-2)
- Benzoic Acid impurity 7 (CAS 83432-87-5)
- Indometacin Impurity 36 (CAS CATO-C4X-147036)
- Lasmiditan Impurity 27 (CAS CATO-C4X-247827)
- 2-(3-Methylphenyl)-4-[3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1,2-dihydrophthalazin-1-one (CAS 1207035-43-5)
- 5-(3,4-Diethoxyphenyl)-3-phenyl-1H-1,2,4-triazole (CAS 1416342-22-7)
- 1-(Cyclopropylmethyl)-3-phenoxybenzene (CAS 1364935-76-1)
- 1-chloro-3-fluoro-2-(4-methylstyryl)benzene (CAS 680214-58-8)
- Methylprednisolone impurity 83 (CAS CATO-C4X-191983)
- Sertraline EP Impurity C HCl (1R,4R-Isomer) (CAS 79617-90-6)
- Tirzepatide Impurity 61 (CAS CATO-C4X-324061)
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