Donepezil Impurity 27 CAS 120013-56-1
| CAS No. | 120013-56-1 |
| Molecular Formula | C23H27NO3 |
| Molecular Weight | 365.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Donepezil Impurity 27.
Donepezil Impurity 27 (CAS 120013-56-1) is a certified pharmaceutical impurity reference standard with the molecular formula C23H27NO3 and a molecular weight of 365.47 g/mol.
Donepezil Impurity 27 (C23H27NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H27NO3 |
| Molecular Weight | 365.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 1 |
Related Donepezil Standards
- Donepezil Impurity 59 (CAS 120013-57-2)
- Donepezil Impurity 47 (CAS 36159-03-2)
- Donepezil EP impurity E (CAS CATO-C4X-103936)
- Donepezil EP impurity F (CAS 145546-80-1)
- Donepezil impurity 32 (CAS 120014-07-5)
- Donepezil Impurity 56 (CAS 608511-44-0)
- Donepezil Impurity 63 (CAS 2230493-73-7)
- Donepezil impurity 70 (CAS CATO-C4X-103970)
Recommended Standards
- tert-Butyl (1-(2-amino-1-(3,4-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)carbamate (CAS 886365-15-7)
- tert-Butyl (1-(2-amino-1-(2,5-dimethoxyphenyl)ethyl)pyrrolidin-3-yl)carbamate (CAS 886364-61-0)
- Amiodarone Impurity 49 (CAS CATO-C4X-142549)
- N~3~-(tert-butyl)-N~2~-(4-methylphenyl)-3,4-dihydro-2,3(1H)-isoquinolinedicarboxamide (CAS 318517-14-5)
- Pyridoxine Trimer(Vitamin B6 Impurity 52) trihydrochloride (CAS 78761-51-0(Free Base))
- Azilsartan Impurity N3 (CAS 147404-82-8)
- Ticagrelor Impurity 54 (CAS CATO-C4X-109354)
- 3-{[(2-Methoxybenzyl)oxy]methyl}piperidinehydrochloride (CAS 1220036-97-4)
- Ethinylestradiol EP Impurity I (CAS 67703-68-8)
- 3-(2,2,2-Trifluoroethoxy)isonicotinaldehyde (CAS 2089310-61-0)
- tert-Butyl (3-cyano-7-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[b]thiophen-2-yl)carbamate (CAS 2761968-90-3)
- 4-Acetyl-2-nitrobenzoic acid (CAS 860597-87-1)
- 4-{[1,1'-Biphenyl]-4-carbonyl}-8-propyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326809-08-8)
- (Tyr9)-Cholecystokinin Octapeptide (sulfated) (H-9770.0005) (CAS 96607-61-3)
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