Donepezil Impurity 47 CAS 36159-03-2
| CAS No. | 36159-03-2 |
| Molecular Formula | C22H22O5 |
| Molecular Weight | 366.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 366.41 g/mol gives Donepezil Impurity 47 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Donepezil Impurity 47 (CAS 36159-03-2, C22H22O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Donepezil Impurity 47 (C22H22O5) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H22O5 |
| Molecular Weight | 366.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
Related Donepezil Standards
- Donepezil Impurity 27 (CAS 120013-56-1)
- Donepezil Impurity 59 (CAS 120013-57-2)
- Donepezil EP impurity E (CAS CATO-C4X-103936)
- Donepezil EP impurity F (CAS 145546-80-1)
- Donepezil impurity 32 (CAS 120014-07-5)
- Donepezil Impurity 56 (CAS 608511-44-0)
- Donepezil Impurity 63 (CAS 2230493-73-7)
- Donepezil impurity 70 (CAS CATO-C4X-103970)
Recommended Standards
- 10-Hydroxyscandine (CAS 119188-47-5)
- Dabigatran Impurity 28 (CAS 1456889-80-7)
- CAS 879973-83-8 (CAS 879973-83-8)
- Felodipine Impurity 40 (CAS CATO-C4X-109440)
- Revefenacin impurity 30 (CAS 1719-82-0)
- Ixazomib Impurity 50 (CAS 220315-20-8)
- Pramipexole Impurity 96 (CAS CATO-C4X-110796)
- 3-Bromo-1-(methoxymethyl)-N,N-dimethyl-1H-1,2,4-triazol-5-amine (CAS 2090280-13-8)
- 2-((3,4-Dimethylphenyl)amino)nicotinic acid (CAS 16396-31-9)
- Benzyl ((3-fluoropyrrolidin-3-yl)methyl)carbamate hydrochloride (CAS 1422344-31-7)
- (2-(Naphthalen-2-yl)phenyl)boronic acid (CAS 1061350-97-7)
- 5-(2-Chloroethyl)-1-methyl-1H-pyrazole hydrochloride (CAS 1797374-16-3)
- (E)-4-(2-(4-((3-chloro-2-methylphenyl)amino)-4-oxobutanoyl)hydrazinyl)-4-oxobut-2-enoic acid (CAS 327070-23-5)
- Insulin Degludec Impurity 9 (CAS CATO-C4X-21579)
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