Donepezil Impurity 7 CAS 120013-84-5
| CAS No. | 120013-84-5 |
| Molecular Formula | C24H29NO4 |
| Molecular Weight | 395.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 395.49 g/mol gives Donepezil Impurity 7 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Donepezil Impurity 7 (CAS 120013-84-5) is a certified pharmaceutical impurity reference standard with the molecular formula C24H29NO4 and a molecular weight of 395.49 g/mol.
The molecular framework of Donepezil Impurity 7 (C24H29NO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Donepezil Impurity 7 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H29NO4 |
| Molecular Weight | 395.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 1 |
Related Donepezil Standards
- Donepezil Impurity 31 (CAS 2097683-67-3)
- Donepezil EP impurity C (CAS 2452407-76-8)
- Donepezil Impurity 51 (CAS CATO-C4X-103951)
- Donepezil Impurity 53 (CAS 149874-81-7)
- Donepezil Impurity 74 (CAS CATO-C4X-103974)
- Donepezil Impurity 15 (CAS 1023500-88-0)
- Donepezil Impurity 40 (CAS 923571-16-8)
- Donepezil D7 (CAS 1215071-00-3)
Recommended Standards
- Naltrexone EP Impurity E (CAS 767615-69-0)
- Alfuzosin-D6 (CAS 1006717-31-2)
- Hydroxydonepezil (CAS 197010-20-1)
- Eplerenone Impurity 23 (CAS CATO-C4X-163023)
- Neostigmine impurity 36 (CAS CATO-C4X-204236)
- Arotinolol Impurity 48 (CAS CATO-C4X-185448)
- Indacaterol Impurity 55 HCl (CAS 2103932-64-3(Free base))
- 4-(4-Ethyl-5-(methylthio)-4H-1,2,4-triazol-3-yl)-1-((4-methoxyphenyl)sulfonyl)piperidine (CAS 672950-64-0)
- n-(Pyridin-3-ylmethyl)cyclohexanamine (CAS 97247-37-5)
- 1,2,2,6,6-PENTAMETHYLPIPERIDINE (CAS 79-55-0)
- a-Amino-1H-indole-2-propanoic acid (CAS 1954-56-9)
- 3-Fluoro-4-(1h-pyrazol-1-yl)benzaldehyde (CAS 433920-88-8)
- 3-Methyl-[1,2,4]triazolo[5,1-c][1,2,4]triazin-4(1H)-one (CAS 57250-39-2)
- Anorexigenic Peptide (CAS 69275-10-1)
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