Galantamine EP Impurity E HBr CAS 1201809-28-0
| CAS No. | 1201809-28-0 |
| Molecular Formula | C16H19NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Galantamine EP Impurity E HBr.
Galantamine EP Impurity E HBr (CAS 1201809-28-0) is a certified pharmaceutical impurity reference standard with the molecular formula C16H19NO3HBr and a molecular weight of 354.24 g/mol.
Galantamine EP Impurity E HBr (C16H19NO3HBr) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H19NO3 HBr |
| Molecular Weight | 354.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Galantamine Standards
- Galantamine-d6 (CAS 1128109-00-1)
- Galantamine EP Impurity F HBr (CAS 1556014-63-1)
- Galantamine EP Impurity B (CAS 1668-85-5)
- Galantamine Hydrobromide Racemic (CAS 193146-85-9)
- Galantamine hydrobromide (CAS 1953-04-4)
- Galantamine Impurity 5 (CAS 199014-26-1)
- Galantamine Impurity 11 (CAS 21041-10-1)
- Galantamine EP Impurity C (CAS 21133-52-8)
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- N-(2-fluorophenyl)-4-hydroxybenzamide (CAS 350029-67-3)
- Semaglutide impurity 70 (CAS CATO-C4X-222670)
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