Diphenhydramine EP Impurity C HCl CAS 1808-12-4
| CAS No. | 1808-12-4 |
| Molecular Formula | C17H20BrNO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Diphenhydramine EP Impurity C HCl (CAS 1808-12-4), a pharmacopoeial impurity reference standard (molecular formula C17H20BrNOHCl, MW 370.71 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Diphenhydramine EP Impurity C HCl (C17H20BrNOHCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 370.71 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Diphenhydramine EP Impurity C HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H20BrNO HCl |
| Molecular Weight | 370.71 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 1 |
Related Diphenhydramine Standards
- Diphenhydramine EP Impurity C (CAS 118-23-0)
- Diphenhydramine-d6 Hydrochloride (CAS 1189986-72-8)
- Diphenhydramine d5 Hydrochloride (CAS 1219795-16-0)
- Diphenhydramine N-Oxide(hydrochloride) (CAS 13168-00-8)
- Diphenhydramine N-Glucuronide (CAS 137908-78-2)
- Diphenhydramine Hydrochloride (CAS 147-24-0)
- Diphenhydramine impurity 18 (CAS 150556-79-9)
- Diphenhydramine EP Impurity A(Dimenhydrinate EP Impurity F) (CAS 17471-10-2)
Recommended Standards
- Cefditoren Impurity 4 (CAS CATO-C4X-13584)
- Digoxin EP Impurity B (CAS 4562-36-1)
- Norepinephrine Impurity 37 (CAS CATO-C4X-151437)
- 1,2-Diiodo-3-methylbenzene (CAS 1608-48-6)
- N-(4-Methylbenzyl)cyclopropanamine (CAS 1213865-94-1)
- 2,6-Dimethoxy-3,7-bis(methyltelluro)-naphthalene (CAS 136559-38-1)
- 5-[(4-benzylpiperidin-1-yl)sulfonyl]-2-hydrazinylpyridine (CAS 926253-38-5)
- [4-(4-Methoxyphenyl)piperazin-1-yl]-(2-piperidyl)methanone (CAS 1325303-18-1)
- Mephenytoin Impurity 1 (CAS 1173022-56-4)
- Tau Peptide (401-411)-Lys-Lys trifluoroacetate salt (CAS 2022956-59-6)
Why CATO?
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