Ixazomib Impurity 29 CAS 1201903-03-8
| CAS No. | 1201903-03-8 |
| Molecular Formula | C42H51B3Cl6N6O9 |
| Molecular Weight | 1029.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Ixazomib Impurity 29 (CAS 1201903-03-8, C42H51B3Cl6N6O9) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Ixazomib Impurity 29 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 1029.04 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C42H51B3Cl6N6O9 |
| Molecular Weight | 1029.04 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Ixazomib Standards
- Ixazomib Impurity 84 (CAS CATO-C4X-126784)
- Ixazomib Impurity 85 (CAS CATO-C4X-126785)
- Ixazomib Impurity 30 (CAS CATO-C4X-126730)
- Ixazomib Impurity 74 (CAS CATO-C4X-126774)
- Ixazomib Impurity 25 (CAS CATO-C4X-126725)
- Ixazomib Impurity 26 (CAS CATO-C4X-126726)
- Ixazomib Impurity 27 (CAS CATO-C4X-126727)
- Ixazomib Impurity 28 (CAS CATO-C4X-126728)
Recommended Standards
- Ruthenium, [(3S)-4,4'-bis(diphenylphosphino-κP)-2,2',6,6'-tetramethoxy-3,3'-bipyridine]dichloro[(1R,2R)-1,2-diphenyl-1,2-ethanediamine-κN1,κN2] (CAS 916826-86-3)
- Dichloro[(S)-(-)-2,2',6,6'-tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine][(1S,2S)-(-)-1,2-diphenylethylenediamine]ruthenium(II) (CAS 821793-36-6)
- [Bis[3,5-bis(trifluoromethyl)phenyl][3,6-dimethoxy-2′,4′,6′-tris(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphine-κP]chlorogold (CAS 1334547-76-0)
- Dichloro[(R)-(+)-2,2',6,6'-tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine][(1R,2R)-(+)-1,2-diphenylethylenediamine]ruthenium(II) (CAS 478308-91-7)
- Iopamidol Impurity 58 (CAS CATO-C4X-145058)
- Upadacitinib Impurity 216 (CAS CATO-C4X-2405216)
- Nizatidine EP Impurity H (CAS 27507-28-4)
- 46492-08-4 7-[6-(3-hydroxyoct-1-en-1-yl)-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enoic acid AR-1H3040 (CAS 46492-08-4)
- 4'-Fluoro-2'-methoxy-5'-isopropyl-4-trifluoromethyl-1,1'-biphenyl-2-methanol (CAS 875548-97-3)
- Myristoyl-Lys-Arg-Thr-Leu-Arg-OH (CAS 125678-68-4)
- 5-(4-Methyl-2-nitrophenyl)pent-4-yn-1-ol (CAS 915402-23-2)
- 1-[4-(Methylsulfonyl)-3-nitrophenyl]pyrrolidine (CAS 1353505-69-7)
- Diethyl phenylphosphonothioate (CAS 6231-03-4)
- Insulin Degludec Impurity 2 (CAS CATO-C4X-21572)
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