N-(2-((2,3-Difluorobenzyl)thio)-6-(((2R,3R)-3,4-dihydroxybutan-2-yl)amino)pyrimidin-4-yl)azetidine-1-sulfonamide CAS 1204707-71-0
| CAS No. | 1204707-71-0 |
| Molecular Formula | C18H23F2N5O4S2 |
| Molecular Weight | 475.53 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of N-(2-((2,3-Difluorobenzyl)thio)-6-(((2R,3R)-3,4-dihydroxybutan-2-yl)amino)pyrimidin-4-yl)azetidine-1-sulfonamide (C18H23F2N5O4S2) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
N-(2-((2,3-Difluorobenzyl)thio)-6-(((2R,3R)-3,4-dihydroxybutan-2-yl)amino)pyrimidin-4-yl)azetidine-1-sulfonamide (CAS 1204707-71-0), molecular formula C18H23F2N5O4S2 and molecular weight 475.53 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H23F2N5O4S2 |
| Molecular Weight | 475.53 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 2 |
Related N Standards
- N-[2-[(2,3-Difluorobenzyl)thio]-6-[[(2R,3S)-3,4-dihydroxy-2-butyl]oxy]-4-pyrimidinyl]azetidine-1-sulfonamide (CAS 878385-84-3)
- N-(2,4-Difluorobenzyl)-2'-((2-(4-methoxyphenyl)acetamido)methyl)-[1,1'-biphenyl]-2-carboxamide (CAS 498577-46-1)
- N-(3,5-Difluorobenzyl)-2-oxo-1-(1-(phenylsulfonyl)-1H-indol-5-yl)pyrrolidine-3-carboxamide (CAS 2575547-28-1)
- (R)-1-(3,4-Difluorobenzyl)-2-oxo-N-(2-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)oxy)-1-phenylethyl)-1,2-dihydropyridine-3-carboxamide (CAS 1001409-50-2)
- 3-(5-((2,6-Difluorobenzyl)thio)-4-(4-ethoxyphenyl)-4H-1,2,4-triazol-3-yl)pyridine (CAS 578762-54-6)
- (1-(3,5-Difluorobenzyl)-4,4-dioxido-1H-benzo[e][1,3,4]thiadiazin-3-yl)(pyrrolidin-1-yl)methanone (CAS 1251630-39-3)
- N-(4-(3-((2,6-Difluorobenzyl)amino)-3-oxopropyl)thiazol-2-yl)benzamide (CAS 1021256-75-6)
- Methyl 2-({[1-(3,4-difluorobenzyl)-6-oxo-1,6-dihydro-3-pyridinyl]carbonyl}amino)benzenecarboxylate (CAS 242797-45-1)
Recommended Standards
- t-Boc-aminocaproicnitrilotriacetic Acid (CAS 1039123-88-0)
- N-[2-[[(2,3-Difluorophenyl)methyl]thio]-6-[[(1S,2R)-2,3-dihydroxy-1-methylpropyl]amino]-4-pyrimidinyl]-1-azetidinesulfonamide (CAS 1204707-73-2)
- Glipizide Impurity 44 (CAS CATO-C4X-140744)
- Sibiromycin (CAS 12684-33-2)
- 1-(2-Methylthiazole-4-carbonyl)pyrrolidine-3-carboxylic acid (CAS 1485008-79-4)
- 3-[(4-Chloro-3,5-dimethylphenoxy)methyl]piperidine (CAS 946787-39-9)
- (2E)-3-[(4-Chlorophenyl)amino]-1-(naphthalen-2-yl)prop-2-en-1-one (CAS 339014-59-4)
- (R)-1-(3-(Ethylamino)pyrrolidin-1-yl)ethanone (CAS 1353996-70-9)
- Sarpogrelate Impurity 17 HCl (CAS 1659311-40-6(free base))
- Butyl (5-(tert-butyl)isoxazol-3-yl)carbamate (CAS 89661-70-1)
- Ethyl 2,2-dihydroxyacetate (CAS 64805-08-9)
- 1-(4-Hydroxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol (CAS 56122-34-0)
- 5-Bromo-6-fluoro-2-methyl-3,4-dihydroquinoline-1(2H)-carbaldehyde (CAS 143703-23-5)
- a2,3-Sialylglycopeptide (CAS 189035-43-6)
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