Rebamipide impurity 20 CAS 1205-74-9
| CAS No. | 1205-74-9 |
| Molecular Formula | 2*C10H10BrNO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Rebamipide impurity 20 (CAS 1205-74-9, C10H10BrNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Rebamipide impurity 20 (C10H10BrNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Rebamipide impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | 2*C10H10BrNO2 |
| Molecular Weight | 256.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Rebamipide Standards
- Rebamipide Impurity 4 (CAS 100342-53-8)
- Rebamipide impurity 25 (CAS 1022283-52-8)
- Rebamipide Impurity 43 (CAS 1028268-32-7)
- Rebamipide-d4 (CAS 1219409-06-9)
- Rebamipide Impurity 12 (CAS 132210-24-3)
- Rebamipide Impurity 60 (CAS 135252-30-1)
- Rebamipide impurity 02 (CAS 1984832-92-9)
- Rebamipide Impurity 37 (CAS 1984832-97-4)
Recommended Standards
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- (Methylene-d2)gibberellin A6 (CAS 120396-37-4)
- 2-(3-Methylpiperidin-3-yl)acetic acid (CAS 1897550-13-8)
- 7-Chloro-1-nitroso-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one (CAS CATO-C3D-262672)
- Tetrahydrofuran-3,4-dicarboxylic acid (CAS 71034-99-6)
- 2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (CAS 166047-40-1)
- 1,3-Diiminoisoindoline (CAS 3468-11-9)
- Tau Peptide (401-411)-Lys-Lys trifluoroacetate salt (CAS 2022956-59-6)
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