Rebamipide Impurity 4 CAS 100342-53-8
| CAS No. | 100342-53-8 |
| Molecular Formula | C18H15ClN2O2 |
| Molecular Weight | 326.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Rebamipide Impurity 4 (CAS 100342-53-8), a pharmacopoeial impurity reference standard (molecular formula C18H15ClN2O2, MW 326.78 g/mol) used for the identification and quantification of trace impurities in APIs.
Rebamipide Impurity 4 (C18H15ClN2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H15ClN2O2 |
| Molecular Weight | 326.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Rebamipide Standards
- Rebamipide impurity 24 (CAS CATO-C4X-152324)
- Rebamipide Impurity 33 (CAS CATO-C4X-152333)
- Rebamipide Impurity 50 (CAS CATO-C4X-152350)
- Rebamipide Impurity 57 (CAS 23976-45-6)
- Rebamipide Impurity 67 (CAS CATO-C4X-152367)
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- Rebamipide impurity 04 (CAS 23974-11-0)
Recommended Standards
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- Ticagrelor Impurity 57 (CAS 1427524-53-5)
- Mometasone Furoate EP Impurity S (CAS 2231764-75-1)
- Tedizolid Impurity 19 (CAS CATO-C4X-105419)
- 2-Chloro-N-(2,4-dimethoxyphenyl)quinazolin-4-amine (CAS 524033-57-6)
- Altrenogest impurity 16 (CAS CATO-C4X-248316)
- 1-Chloro-4-methanesulfinylbutane (CAS 53394-81-3)
- 2-Fluoro-2-(1H-imidazol-1-yl)acetic acid (CAS 861397-68-4)
- 6-Chloro-2-methylpyrimidine-4,5-diamine (CAS 933-80-2)
- 3,5-Diacetoxybenzamide (CAS 61227-18-7)
- D-Leu14-Tirzepatide (CAS CATO-CPTD788920)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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