Acetaminophen impurity 29 CAS 120595-80-4
| CAS No. | 120595-80-4 |
| Molecular Formula | C14H16NO8 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Acetaminophen impurity 29.
CATO supplies Acetaminophen impurity 29 (CAS 120595-80-4), a pharmacopoeial impurity reference standard (molecular formula C14H16NO8Na, MW 349.27 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Acetaminophen impurity 29 (C14H16NO8Na) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H16NO8 Na |
| Molecular Weight | 349.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 1 |
Related Acetaminophen Standards
- Acetaminophen Impurity 30 (CAS 100-00-5)
- Acetaminophen EP Impurity F (CAS 100-02-7)
- 4-Acetaminophen Sulfate (CAS 10066-90-7)
- Acetaminophen Impurity 44 (CAS 102019-96-5)
- 4-Acetaminophen-D3 Sulfate (CAS 1020718-78-8)
- Acetaminophen EP impurity D (CAS 103-84-4)
- Acetaminophen Impurity 42 (CAS 1075742-56-1)
- Acetaminophen-d3 Sulphate Potassium Salt (CAS 1188263-45-7)
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- 1-ethyl-2,6-difluoro-1H-1,3-benzodiazole (CAS 2297543-94-1)
- 1,3-bis(fluoranyl)propan-2-one 1,3-difluoro-2-propanone 453-14-5 A826770 (CAS 453-14-5)
- 1-(5-fluoro-1-phenyl-1H-pyrazol-4-yl)ethan-1-one (CAS 1691000-51-7)
- Osteogenic Growth Peptide (10-14) (CAS 105250-85-9)
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