Acetaminophen EP impurity D CAS 103-84-4
| CAS No. | 103-84-4 |
| Molecular Formula | C8H9NO |
| Molecular Weight | 135.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Acetaminophen EP impurity D is typically off-white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 135.16 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Acetaminophen EP impurity D (CAS 103-84-4, C8H9NO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Acetaminophen EP impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H9NO |
| Molecular Weight | 135.16 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Acetaminophen Standards
- Acetaminophen EP Impurity F (CAS 100-02-7)
- Acetaminophen-13C2, 15N1 (CAS 360769-21-7)
- Acetaminophen-d3 (CAS 60902-28-5)
- Acetaminophen Impurity 32 (CAS 874-60-2)
- Acetaminophen-d4 (major) (CAS 64315-36-2)
- Acetaminophen Impurity 30 (CAS 100-00-5)
- Acetaminophen Impurity 31 (CAS 587-65-5)
- Acetaminophen Impurity 34 (CAS 146897-60-1)
Recommended Standards
- Linagliptin Impurity 59 (CAS 551-93-9)
- Fosfomycin Impurity 78 (CAS 74178-02-2)
- Erlotinib Impurity 112 (CAS 99-03-6)
- Clenbuterol EP impurity D (CAS 99-92-3)
- Clotrimazole Impurity 15 (CAS 2136-81-4)
- Linagliptin Impurity N26 (CAS 397246-12-7)
- Imidafenacin Impurity N1 (CAS 562091-56-9)
- 2-(But-3-en-1-yl)-5-methylcyclopentanone (CAS 38382-17-1)
- 4-(2,2-Dimethylmorpholin-4-yl)-2-methoxyaniline (CAS 1411418-67-1)
- Solriamfetol Impurity 14 (CAS CATO-C4X-256314)
- Ethyl 2-amino-3-chloro-4-methylbenzoate (CAS 1506883-04-0)
- N-((1S,2S)-2-((3,5-Di-tert-butyl-2-ethoxyphenyl)selanyl)-2,3-dihydro-1H-inden-1-yl)-1,1,1-trifluoromethanesulfonamide (CAS 2369588-25-8)
- 2-Chloro-N-[4-(hydrazinocarbonyl)phenyl]benzamide (CAS 885559-50-2)
- Semaglutide impurity 244(Fmoc-His(Fmoc)-Aib-OH) (CAS CATO-C4X-2226244)
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