2-Bromo-3,5-dichloropyrazine CAS 1206249-40-2
| CAS No. | 1206249-40-2 |
| Molecular Formula | C5H3ClN4 |
| Molecular Weight | 154.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Bromo-3,5-dichloropyrazine.
2-Bromo-3,5-dichloropyrazine (CAS 1206249-40-2) is a high-purity analytical reference standard with the molecular formula C5H3ClN4 and a molecular weight of 154.56 g/mol.
The molecular framework of 2-Bromo-3,5-dichloropyrazine (C5H3ClN4) is characterized by a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H3ClN4 |
| Molecular Weight | 154.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
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Recommended Standards
- 5-Chloro-1H-imidazo[4,5-b]pyrazine (CAS 1196151-76-4)
- 6-Chloro-3H-[1,2,3]triazolo[4,5-c]pyridine (CAS 120641-09-0)
- 5-Chloro-1H-pyrazolo[3,4-b]pyrazine (CAS 116527-52-7)
- 8-Chloro-[1,2,4]triazolo[4,3-c]pyrimidine (CAS 1208083-81-1)
- 2-(4-Methyl-1h-indol-3-yl)ethan-1-amine (CAS 62500-89-4)
- 2-(Cyclohexylamino)isonicotinic acid (CAS 1019461-35-8)
- 4-Chloro-2-(4-methoxyphenyl)-5-methylquinazoline (CAS 885277-29-2)
- ethyl 7-bromo-4-oxo-pyrido[1,2-a]pyrimidine-3-carboxylate (CAS 16867-56-4)
- Methyl 2-(1-methylpyrrolidin-2-yl)acetate (CAS 51856-76-9)
- 1-(Diethylaminomethyl) cyclopentanecarboxaldehyde (CAS 208349-33-1)
- {[4-(Benzyloxy)phenyl]methyl}(diphenylmethyl)amine (CAS 774193-22-5)
- Daptomycin Impurity 23 (CAS CATO-C4X-137823)
- 6-Bromopyridine-3-thiol (CAS 64007-57-4)
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