2-Chloro-1-(difluoromethyl)-3-(trifluoromethyl)benzene CAS 1214347-72-4
| CAS No. | 1214347-72-4 |
| Molecular Formula | C8H4ClF5 |
| Molecular Weight | 230.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Chloro-1-(difluoromethyl)-3-(trifluoromethyl)benzene (CAS 1214347-72-4), molecular formula C8H4ClF5 and molecular weight 230.56 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2-Chloro-1-(difluoromethyl)-3-(trifluoromethyl)benzene (C8H4ClF5) contains fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 230.56 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4ClF5 |
| Molecular Weight | 230.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 3-Chloro-1,4-difluoro-2-(2,2,2-trifluoroethyl)-benzene (CAS 1099598-14-7)
- 1-Chloro-2,4-difluoro-3-(2,2,2-trifluoroethyl)-benzene (CAS 1099598-22-7)
- 1-Chloro-4-(perfluoroethyl)benzene (CAS 118559-17-4)
- 1-Chloro-4-(difluoromethyl)-2-(trifluoromethyl)benzene (CAS 1214338-35-8)
- 2-Chloro-1-(difluoromethyl)-4-(trifluoromethyl)benzene (CAS 1214348-45-4)
- 1-Chloro-2-(difluoromethyl)-4-(trifluoromethyl)benzene (CAS 1214383-34-2)
- 2-Chloro-4-(difluoromethyl)-1-(trifluoromethyl)benzene (CAS 1214386-92-1)
- 1-Chloro-3-(perfluoroethyl)benzene (CAS 309-13-7)
Recommended Standards
- Germanium(IV) selenide (99.999%-Ge) PURATREM (CAS 12065-11-1)
- 1-(Chloromethyl)-2,3-difluoro-4-(trifluoromethyl)benzene (CAS 1357624-18-0)
- 1-(Chlorodifluoromethyl)-4-(trifluoromethyl)benzene (CAS 13947-94-9)
- 5-Chloro-2-fluoro-4-methoxy-6-(trifluoromethyl)pyrimidine (CAS 84737-35-9)
- 2,4-Diamino-5-(trifluoromethyl)pyridine (CAS 1227571-62-1)
- 4-(4-Oxo-3,4-dihydroquinazolin-3-yl)butanoic acid (CAS 25818-89-7)
- 3-Fluoro-2-(neopentyloxy)pyridine (CAS 1704066-70-5)
- 6-Methylpyrimidin-4(1H)-one (CAS 156647-95-9)
- [1-(2-phenylethyl)piperidin-4-yl]methanol (CAS 67686-02-6)
- 2-(methylsulfanyl)-7H,8H-pyrido[2,3-d]pyrimidin-7-one (CAS 211244-81-4)
- 2,6-Bis(2,2,2-trifluoroacetyl)cyclohexanone (CAS 672956-75-1)
- Ethyl 3-chloro-5-methyl-2-oxohexanoate (CAS 111055-64-2)
- 4-Allyl-1,2,5-trimethylpiperidin-4-ol (CAS 117273-47-9)
- Human glucagon CRS (CAS 9007-92-5)
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