4,4'-Difluoro-[1,1'-biphenyl]-3-ol CAS 1214367-64-2
| CAS No. | 1214367-64-2 |
| Molecular Formula | C12H8F2O |
| Molecular Weight | 206.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4,4'-Difluoro-[1,1'-biphenyl]-3-ol (C12H8F2O) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
4,4'-Difluoro-[1,1'-biphenyl]-3-ol (CAS 1214367-64-2) is a high-purity analytical reference standard with the molecular formula C12H8F2O and a molecular weight of 206.19 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4,4'-Difluoro-[1,1'-biphenyl]-3-ol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8F2O |
| Molecular Weight | 206.19 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Difluoro Standards
- 2,4-Difluoro-3-(pyridin-4-yl)aniline (CAS 100325-60-8)
- 3',4'-Difluoro-[1,1'-biphenyl]-3-ol (CAS 1027207-72-2)
- 3',4'-Difluoro-[1,1'-biphenyl]-4-ol (CAS 108185-80-4)
- 2',4-Difluoro-[1,1'-biphenyl]-3-ol (CAS 1214341-66-8)
- 2',5-Difluoro-[1,1'-biphenyl]-3-ol (CAS 1214345-59-1)
- 2,2'-Difluoro-[1,1'-biphenyl]-4-ol (CAS 1214375-77-5)
- 2,6-Difluoro-4-(pyridin-4-yl)aniline (CAS 1214387-96-8)
- 4,5-difluoro-1H-1,3-benzodiazole-2-carboxylic acid (CAS 1225283-27-1)
Recommended Standards
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- 3'-(Benzylamino)-3'-deoxyadenosine (CAS 67313-10-4)
- 2-(2-azidoethyl)-2,3-dihydro-1H-isoindole-1,3-dione (CAS 30250-66-9)
- 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (CAS 119410-84-3)
- Semaglutide impurity 244(Fmoc-His(Fmoc)-Aib-OH) (CAS CATO-C4X-2226244)
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