4-((3-Chlorobenzyl)oxy)-1H-indole-2-carboxylic acid CAS 1215609-58-7
| CAS No. | 1215609-58-7 |
| Molecular Formula | C16H12ClNO3 |
| Molecular Weight | 301.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-((3-Chlorobenzyl)oxy)-1H-indole-2-carboxylic acid.
CATO supplies 4-((3-Chlorobenzyl)oxy)-1H-indole-2-carboxylic acid (CAS 1215609-58-7), a certified reference material (molecular formula C16H12ClNO3, MW 301.72 g/mol) for analytical method development and quality control.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, 4-((3-Chlorobenzyl)oxy)-1H-indole-2-carboxylic acid is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 301.72 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H12ClNO3 |
| Molecular Weight | 301.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chlorobenzyl Standards
- 2-((4-Chlorobenzyl)oxy)isoquinoline-1,3(2H,4H)-dione (CAS 320420-22-2)
- 3-(4-Chlorobenzyl)-6-fluoro-2-methoxyquinoline (CAS 1355229-67-2)
- 5-(3-Chlorobenzyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione (CAS 791717-23-2)
- 4-(4-(2-Chlorobenzyl)piperazin-1-yl)aniline (CAS 640759-22-4)
- 1-Benzyl-3-(4-chlorobenzyl)piperazine (CAS 489437-81-2)
- 2-((3-Chlorobenzyl)thio)-1-phenyl-1H-imidazole (CAS 478046-10-5)
- (E)-1-(3-chlorobenzyl)-3-(4-methylstyryl)urea (CAS 339278-61-4)
- 2-(4-Chlorobenzyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one (CAS 62085-82-9)
Recommended Standards
- 2-Chloro-N-(4-fluorobenzyl)pyrimidine-5-sulfonamide (CAS 1156120-41-0)
- methyl 3-(7-chloro-1-oxo-2,3-dihydro-1H-isoindol-2-yl)benzoate (CAS 1245646-74-5)
- 4-{[(tert-butoxy)carbonyl]amino}-5-chloro-2-methoxybenzoic acid (CAS 1155137-33-9)
- 2-[(3-Chloro-4-fluorophenyl)amino]pyridine-3-sulfonamide (CAS 1341009-16-2)
- 5-(4-Bromophenyl)oxazole-4-carboxylic acid (CAS 1249008-71-6)
- 1-(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylic acid (CAS 842971-60-2)
- (r)-6-Fluoro-2-(piperidin-3-yl)isoindolin-1-one hydrochloride (CAS 1643571-00-9)
- 2-(2-Chlorophenyl)-2,3-dihydroquinolin-4(1H)-one (CAS 668998-36-5)
- 4-Acetamido-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamide (CAS 844440-86-4)
- 6-Methoxy-3-(prop-2-yn-1-yl)benzo[d]thiazol-2(3H)-imine hydrobromide (CAS 127346-14-9)
- Methyl 2-(4-amino-1h-indol-1-yl)acetate (CAS 1343385-31-8)
- (1R,3S,6S,7S)-4-oxatricyclo[4.2.1.0^{3,7}]nonan-2-one (CAS 1864003-34-8)
- Apixaban Impurity 22 (CAS 1449510-64-8)
- (D-His1)-Exenatide trifluoroacetate salt (CAS 1678417-09-8)
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