Atorvastatin Impurity 70 CAS 1217751-95-5
| CAS No. | 1217751-95-5 |
| Molecular Formula | C37H43FN2O5 |
| Molecular Weight | 614.75 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Atorvastatin Impurity 70 (CAS 1217751-95-5, C37H43FN2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Atorvastatin Impurity 70 (C37H43FN2O5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Atorvastatin Impurity 70 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C37H43FN2O5 |
| Molecular Weight | 614.75 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Atorvastatin Standards
- Atorvastatin Impurity 78 (CAS 2588261-38-3)
- Atorvastatin Pyrrolidone Analog (USP) (CAS 691844-60-7)
- Atorvastatin EP Impurity N (CAS 134395-00-9)
- Atorvastatin Impurity 69 (CAS CATO-C4X-113269)
- Atorvastatin Impurity 71 (CAS CATO-C4X-113271)
- Atorvastatin Lactam Allyl Ester (CAS 1246812-55-4)
- Atorvastatin Impurity 65 (CAS 134394-98-2)
- Atorvastatin Impurity 39 (CAS 1353049-81-6)
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