Atorvastatin Impurity 39 CAS 1353049-81-6
| CAS No. | 1353049-81-6 |
| Molecular Formula | C37H41FN2O5 |
| Molecular Weight | 612.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Atorvastatin Impurity 39 (CAS 1353049-81-6, C37H41FN2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Atorvastatin Impurity 39 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 612.73 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C37H41FN2O5 |
| Molecular Weight | 612.73 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Atorvastatin Standards
- Atorvastatin Impurity 65 (CAS 134394-98-2)
- Atorvastatin Lactam Allyl Ester (CAS 1246812-55-4)
- Atorvastatin Impurity 78 (CAS 2588261-38-3)
- Atorvastatin Pyrrolidone Analog (USP) (CAS 691844-60-7)
- Atorvastatin EP Impurity N (CAS 134395-00-9)
- Atorvastatin Impurity 69 (CAS CATO-C4X-113269)
- Atorvastatin Impurity 70 (CAS 1217751-95-5)
- Atorvastatin Impurity 71 (CAS CATO-C4X-113271)
Recommended Standards
- 3-Methoxy-2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yl 4-methylbenzenesulfonate (CAS 2874309-18-7)
- Cyclo(-D-Glu-Ala-D-allo-Ile-Leu-D-Trp) (CAS 136553-74-7)
- 2-((4-Chloro-N-(2,4-dichloro-5-(2-methoxyethoxy)phenyl)phenyl)sulfonamido)-N-(3,5-dichlorophenyl)acetamide (CAS 338967-65-0)
- (E)-2-[2-[2-[[5-[4-[Boc-(methyl)amino]styryl]-2-pyridyl]oxy]ethoxy]ethoxy]ethyl 4-Methylbenzenesulfonate (CAS 1205550-99-7)
- Sarecycline Impurity 2 (CAS CATO-C4X-27982)
- Prednisolone Impurity 62 (CAS CATO-C4X-173762)
- Empagliflozin impurity 02 (CAS 1620758-31-7&1620758-32-8)
- 4-(2-Oxo-4-vinyloxazolidin-3-yl)benzonitrile (CAS 220060-42-4)
- Carmellose (Y0001214) (CAS 9000-11-7)
- 1-(2-(6-Morpholinopyridin-3-yl)pyrrolidin-1-yl)ethanone (CAS 1352506-69-4)
- (R)-Ethyl chroman-2-carboxylate (CAS 137590-28-4)
- 3-(Morpholine-4-sulfonyl)thiophene-2-carboxylic acid (CAS 878466-29-6)
- 3,4-(Isopropylidenedioxy) Shikimic Acid Methyl Ester Acetate (CAS 143308-74-1)
- Human glucagon CRS (CAS 9007-92-5)
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