3-(4-(3-(Trifluoromethyl)phenoxy)pyridin-2-yl)-1,2,4-oxadiazol-5(4H)-one CAS 1219453-91-4
| CAS No. | 1219453-91-4 |
| Molecular Formula | C14H8F3N3O3 |
| Molecular Weight | 323.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-(4-(3-(Trifluoromethyl)phenoxy)pyridin-2-yl)-1,2,4-oxadiazol-5(4H)-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-(4-(3-(Trifluoromethyl)phenoxy)pyridin-2-yl)-1,2,4-oxadiazol-5(4H)-one (CAS 1219453-91-4), molecular formula C14H8F3N3O3 and molecular weight 323.23 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 3-(4-(3-(Trifluoromethyl)phenoxy)pyridin-2-yl)-1,2,4-oxadiazol-5(4H)-one is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 323.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(4-(3-(Trifluoromethyl)phenoxy)pyridin-2-yl)-1,2,4-oxadiazol-5(4H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H8F3N3O3 |
| Molecular Weight | 323.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Trifluoromethyl Standards
- 6-(Trifluoromethyl)-N2-(3-(trifluoromethyl)phenyl)-1,3,5-triazine-2,4-diamine (CAS 36108-11-9)
- N-(4-(3-(Trifluoromethyl)phenoxy)but-2-yn-1-yl)furan-2-carboxamide (CAS 1421450-68-1)
- N-(2-(3-(Trifluoromethyl)-1H-pyrazol-1-yl)ethyl)benzofuran-2-carboxamide (CAS 1448026-99-0)
- 2-({[2-Methyl-3-(trifluoromethyl)phenyl]amino}carbonyl)benzoic acid (CAS 2197063-21-9)
- 7-(1-(3-(Trifluoromethyl)phenoxy)ethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine (CAS 306979-68-0)
- N-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)benzamide (CAS 905432-74-8)
- N-(3-(trifluoromethyl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide (CAS 294853-44-4)
- 3-(Trifluoromethyl)-4-({[4-(trifluoromethyl)phenyl]amino}methylidene)-4,5-dihydro-1H-pyrazol-5-one (CAS 477851-08-4)
Recommended Standards
- 9-Bromo-7,7-dimethyl-7H-benzo[c]fluorene (CAS 1198396-46-1)
- 3-(4-(3-(Trifluoromethoxy)phenyl)pyridin-2-yl)-1,2,4-oxadiazol-5(4H)-one (CAS 1219453-94-7)
- 2-Bromo-11,11-dimethyl-11H-benzo[b]fluorene (CAS 1198396-39-2)
- 3-(4-(2-(Trifluoromethoxy)phenyl)pyridin-2-yl)-1,2,4-oxadiazol-5(4H)-one (CAS 1219453-95-8)
- Diethyl naphthalen-1-ylphosphonate (CAS 25944-75-6)
- 7-Methoxy-4-methylquinazoline (CAS 3219-35-0)
- 1-(2-Ethoxybenzoyl)-2-methylpiperazine (CAS 1240578-04-4)
- 5-Amino-1,3-thiazole-4-carbonitrile (CAS 31785-15-6)
- Pentadecanoic Acid N-Hydroxysuccinimide Ester (CAS 823780-38-7)
- 3-(4-Chlorophenyl)-N-cyclopentylbenzo[c]isoxazole-5-carboxamide (CAS 924823-86-9)
- (5,5-Difluoro-1-methylpiperidin-3-yl)methanol (CAS 2757097-14-4)
- 2-(Bromoacetyl)-1,3-thiazole (CAS 3292-77-1)
- 2-Amino-N-(1-isopropyl-1H-pyrazol-5-yl)propanamide (CAS 1290861-76-5)
- Tirzepatide Impurity 10 (CAS CATO-C4X-324010)
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