Indapamide Impurity 18 CAS 122-01-0
| CAS No. | 122-01-0 |
| Molecular Formula | C7H4Cl2O |
| Molecular Weight | 175.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 175.01 g/mol gives Indapamide Impurity 18 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Indapamide Impurity 18 (CAS 122-01-0, C7H4Cl2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Indapamide Impurity 18 (C7H4Cl2O) is characterized by a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4Cl2O |
| Molecular Weight | 175.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Indapamide Standards
- Indapamide Impurity 43 (CAS CATO-C4X-140043)
- Indapamide EP Impurity A (Mixture of Diastereomers) (CAS 85440-79-5)
- Indapamide Impurity 12 (CAS CATO-C4X-140012)
- Indapamide Impurity 48 (CAS CATO-C4X-140048)
- Indapamide EP Impurity C (CAS 31529-46-1)
- Indapamide EP Impurity C (CAS 77083-51-3)
- Indapamide Impurity 20 (CAS 53406-41-0)
- Indapamide Impurity 9 (CAS 1939-76-0)
Recommended Standards
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- 2-Chlorobenzoyl Chloride (CAS 609-65-4)
- Prasugrel Impurity 14 (CAS 178688-43-2)
- Aripiprazole Impurity 90 (CAS CATO-C4X-100890)
- Carbocisteine Impurity 9 (CAS 87862-95-1)
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- 5-Bromo-2-chloro-N-(2,2-dimethoxyethyl)benzamide (CAS 477772-67-1)
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