2,4-Dichlorobenzyl Alcohol EP Impurity F CAS 874-42-0
| CAS No. | 874-42-0 |
| Molecular Formula | C7H4Cl2O |
| Molecular Weight | 175.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 175.01 g/mol gives 2,4-Dichlorobenzyl Alcohol EP Impurity F distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2,4-Dichlorobenzyl Alcohol EP Impurity F (CAS 874-42-0) is a certified pharmaceutical impurity reference standard with the molecular formula C7H4Cl2O and a molecular weight of 175.01 g/mol.
Structurally, 2,4-Dichlorobenzyl Alcohol EP Impurity F (C7H4Cl2O) contains a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 175.01 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4Cl2O |
| Molecular Weight | 175.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Dichlorobenzyl Standards
- 3,5-Dichlorobenzyl alcohol (CAS 60211-57-6)
- 2,3-Dichlorobenzyl alcohol (CAS 38594-42-2)
- 2,4-Dichlorobenzyl Alcohol EP Impurity A (CAS 34145-05-6)
- 2,4-Dichlorobenzyl Alcohol EP Impurity C (CAS 1805-32-9)
- 2,6-Dichlorobenzyl Alcohol (CAS 15258-73-8)
- 2,4-Dichlorobenzyl Alcohol (CAS 1777-82-8)
- 2,5-Dichlorobenzyl cyanide (CAS 3218-50-6)
- (2,3-Dichlorobenzyl)hydrazine (CAS 51421-26-2)
Recommended Standards
- Indapamide Impurity 18 (CAS 122-01-0)
- 2-Chlorobenzoyl Chloride (CAS 609-65-4)
- Ixazomib Impurity 15 (CAS 10203-08-4)
- 1-Iodopropane-2,2,3,3,3-d5 (stabilized with copper) (CAS 1095269-04-7)
- Minodronic Impurity 22 (CAS 1507308-67-9)
- Propofol Impurity 60 (CAS CATO-C4X-147360)
- Erlotinib impurity 137 (CAS 1318599-96-0)
- FA-Gly-Nva-NH2 (M-1830.0250) (CAS 67607-50-5)
- 2,2'-(1,2-Phenylene)bis(N,N-dimethylbenzo[d]oxazol-6-amine) (CAS 920491-91-4)
- 4-(Hydroxymethyl)-5-(phenylamino)-2H-pyrrol-2-one (CAS 55876-73-8)
- 2-Fluoroaniline hydrochloride (CAS 51085-49-5)
- 4-Chloro-2-methyl-3-nitroquinoline (CAS 79358-29-5)
- 3-Amino-N-phenylbenzofuran-2-carboxamide (CAS 361991-92-6)
- Liraglutide Impurity 10 TFA Salt (CAS CATO-C4X-199210)
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