Isoxazolo[4,5-b]pyridin-3(2H)-one CAS 122019-40-3
| CAS No. | 122019-40-3 |
| Molecular Formula | C6H4N2O2 |
| Molecular Weight | 136.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Isoxazolo[4,5-b]pyridin-3(2H)-one (CAS 122019-40-3), molecular formula C6H4N2O2 and molecular weight 136.11 g/mol, is a CATO reference standard with documented purity and traceability.
Isoxazolo[4,5-b]pyridin-3(2H)-one (C6H4N2O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4N2O2 |
| Molecular Weight | 136.11 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 2 |
Related Isoxazolo Standards
- Isoxazolo[5,4-c]pyridazin-3-amine (CAS 1543119-63-6)
- Isoxazolo[5,4-b]pyridin-3-ol (CAS 16880-54-9)
- Isoxazolo[4,5-b]pyrazin-3-amine (CAS 81411-79-2)
- Isoxazolo[5,4-c]pyridin-3(2H)-one (CAS 847996-42-3)
- Isoxazolo[5,4-d]pyrimidin-4-amine (CAS 632291-82-8)
- Isoxazolo[4,5-b]pyridin-3-amine (CAS 114080-93-2)
- Isoxazolo[5,4-c]pyridin-3-amine (CAS 114080-94-3)
- Isoxazolo[4,5-c]pyridin-3-amine (CAS 1229383-25-8)
Recommended Standards
- Oxazolo[5,4-b]pyridin-2(1H)-one (CAS 118767-92-3)
- [1,4]Dioxino[2,3-d]pyrimidine (CAS 128446-95-7)
- 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetonitrile (CAS 1184639-97-1)
- 7H-Purin-8(9H)-one (CAS 13230-97-2)
- 2-(4-Chlorophenyl)-5-methyl-1h-pyrazol-3-one (CAS 20629-92-9)
- Methyl 5-chloro-2-ethylisonicotinate (CAS 1256791-59-9)
- Sodium dihydrogen phosphate (CAS 7758-80-7)
- tert-Butyl Piperidin-1-ylcarbamate (CAS 126216-45-3)
- (3-(Morpholinomethyl)phenyl)(3-(trifluoromethyl)phenyl)methanone (CAS 898791-98-5)
- (4-(N,N-Dimethylsulfamoyl)-3-methylphenyl)boronic acid (CAS 1778667-15-4)
- n1-Cyclobutyl-n2,n2-dimethylethane-1,2-diamine (CAS 1249157-50-3)
- Diethyl N-[(1S,2S)-2-[(1-naphthalenylmethyl)amino]cyclohexyl]phosphoramidate (CAS 1792981-76-0)
- 4-{[2-(2-Pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl]oxy}benzenecarbonitrile (CAS 338754-15-7)
- Des-Leu14-Tirzepatide (CAS CATO-CPTD788959)
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